This report is a complete international focus on the orthopedic biomaterials market. Orthopedic biomaterial products, which can be organic or synthetic in nature, are implanted into or near a bone fracture to facilitate healing or to compensate for a lack or loss of bone tissue. Biomaterials used in orthopedic surgery include autografts, allografts, xenografts, ceramics, polymers, bone growth factors and synovial fluid substitutes. Among the prominent applications for orthopedic biomaterials are surface coatings for hip prostheses, bone cements, bone defect fillers, and fracture fixation plates.

This report focuses on orthopedic biomaterials. The specific areas covered in this report are the products and markets for bone allografts and bone graft substitutes, which include allograft bone substitutes, ceramic-based, polymer-based, factor-based (recombinant growth factors) and hyaluronic acid synovial fluid substitutes.

Kalorama's Orthopedic Biomaterials, World Market, one of the few resources available on this market, includes the following segments:

• Allograft Products (including DBM, Machined Bone and Standard Allograft)
• Ceramic Products
• Polymer Products
• rhBMP Products
• HA Viscosupplemental Products

As part of Kalorama Information's exhaustive coverage of the orthopedic biomaterials market for each area, the following data are provided:

• Historical Revenues from 2006-2010
• Forecasts to 2016
• Competitive Market Share
• Discussion of Issues and Trends
• Review of New Products
• Company Profiles

A truly global resource, this report provides information on the following world regions:

• US
• Europe
• Asia
• Rest of World

The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment reports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study, Kalorama Information conducted interviews with key industry officials, consultants, health care providers, orthopedic surgeons, research institutes, and government personnel. These sources were the primary basis for information specifically relating to trends in the orthopedic biomaterials industry, revenue and market share data presented in this report. Specific interviews with orthopedic implant device and biomaterial company representatives included marketing directors, division managers, and product representatives.

Company profiles are provided for the following companies:

• Allograft Tissue Systems, Inc.

• Alphatec Spine, inc.
• Anika Therapeutics, Inc.
• ApaTech, Inc.
• Artimplant usa
• Berkeley Advanced Biomaterials, Inc.
• Biocoat, Inc.
• Biocomposites Ltd
• Biocoral, Inc.
• Biomatlante
• Biomet, Inc.
• BioMimetic Therapeutics, Inc.
• CAM Bioceramics
• CeraPedics LLC
• Collagen Matrix, Inc.
• Curasan, Inc.
• DePuy, Inc.
• Etex Corporation
• Exactech, Inc.
• Genzyme Corporation
• Globus Medical, Inc.
• Integra LifeSciences Corporation
• Invibio, Inc.
• Kensey Nash Corporation
• Landec Corporation
• Medtronic, Inc.
• Mesoblast Limited
• NovaBone Products LLC
• NuVasive, Inc.
• Olympus Biotech Corporation
• Orthofix Inc.
• Orthovita, Inc
• Osiris Therapeutics
• Osprey Biomedical
• Pioneer Surgical Technology, Inc.
• RepRegen Limited
• RTI biologics Inc.
• Seikagaku Corporation
• Smith & Nephew, Inc.
• Stryker Orthopedics
• Synthes, Inc
• Teknimed SA
• TiGenix NV
• Tornier, INC.
• Wright Medical Group, Inc.
• Zimmer Holdings, Inc.

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Additional Information

Orthopedic Device Makers Seek to Boost Profits with Biomaterial Products

Advances in gene therapy and stem cell research are driving the market for orthopedic biomaterials, notes Kalorama Information in its recently published report, Orthopedic Biomaterials, the World Market. According to the healthcare market research firm, the orthopedic biomaterials market represents 14% of the global orthopedics market, or about $5.8 billion in 2010, with double digit annual growth expected through 2016.

Musculoskeletal conditions are the most common cause of chronic disability. These conditions comprise over 150 diseases and syndromes, which are usually progressive and associated with pain. They can broadly be categorized as joint diseases, physical disabilities, spinal disorders, and conditions resulting from trauma. Those conditions with the greatest impact on society include rheumatoid arthritis, osteoarthritis, osteoporosis, lower back pain, and limb trauma. Approximately 2 million bone-grafting procedures in the spine, extremities and pelvis are performed each year on a worldwide basis.

"Advances in gene therapy and stem cell research may offer new solutions for state-of-the-art treatments for these musculoskeletal conditions," notes Bruce Carlson, publisher of Kalorama Information. "Many researchers believe that genetically engineered stem cells will have a significant impact on the fields of regenerative medicine and tissue engineering as a powerful cell source that will work, in conjunction with biomaterials, to treat tissue and bone loss."

Two areas in biomaterials that have gained significant momentum in recent years are growth factor-based and cell-based bone graft substitutes. Growth factor-based recombinant bone morphogenetic proteins (BMPs) include recombinant human bone morphogenetic protein 2 (BMP-2) and recombinant human osteogenic protein-1 (BMP-7), which are used as autologous bone graft substitutes. Cell-based bone substitutes are considered by some to be the wave of the future and include Mesenchymal stem cells. These are involved in osteogenic differentiation of cells at the site of bone generation and used in the allograft bone substitutes currently on the market.

"As standard orthopedics gets more competitive, biomaterials have become an area of interest for companies like Stryker, J&J, Wright and Zimmer," notes Carlson.

Kalorama Information's Orthopedic Biomaterials, the World Market looks at the products and markets for bone allografts and bone graft substitutes, which include allograft bone substitutes, ceramic-based, polymer-based, factor-based (recombinant growth factors) and hyaluronic acid synovial fluid substitutes. Coverage includes historical revenues from 2006-2010, forecasts to 2016, competitive market share, a discussion of issues and trends, a review of new products, and profiles of key companies in the field.

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