Vaccines: World Market Analysis, Key Players, and Critical Trends in a Fast-Changing Industry

Apr 1, 2008
230 Pages - Pub ID: KLI1682234
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Few areas of pharmaceuticals have seen the fast-moving developments in the marketplace that the vaccine market has in 2007 and 2008. Since Kalorama Information last updated Kalorama Information's The World Market for Vaccines in the first quarter of last year, new products and better than expected profits have transformed the vaccine marketplace. Approvals that have been granted for products such as RotaTeq, Pentacel, Adacel and Zostavax and FluMist are now impacting the market. The launch and execution of the first successful cancer vaccine product, Merck's Gardasil, has had dramatic and surprising results. Other products also exceeded revenue expectations. The competitive dynamics have changed with merger activity, and many new products are on the way.

Kalorama vaccine market analyst Allison Sahoo's exhaustive research and analysis of interviews with key decision makers in the market includes the following:

  • Review of Products in the Market
  • Current World Market Size for Pediatric and Adult Vaccines
  • Segmented Revenues and Forecasts to 2013 by Category
  • Over 45 Charts and Tables To Make Information Accessible
  • Important Vaccines and Immunization Schedules and Statistics
  • Discussion of Issues and Trends in the Vaccine Market
  • Profiles of 15 Key Vaccine Companies
  • Thorough Review of the Vaccine Pipeline and Possible Impact of New Products
Who are the main players in the vaccine market? What opportunities are available for pharmaceutical companies or investors from this market? What are the potential challenges vaccine competitors must deal with? What will be the impact of the first successful cancer product? What is the significance of at least one major acquisition to affect this industry? These questions and more are tackled in this report.

Current revenues and revenue forecasts to 2013 are included for the following pediatric vaccine categories:

  • DTaP & DTP Vaccines
  • Hep Vaccines
  • HiB Vaccines
  • MMR Vaccines
  • Combination Vaccines
  • Pneumococcal Vaccines
  • Polio Vaccines
  • Varicella Vaccines
  • Other Pediatric Vaccines

As well as Revenues and Forecasts to 2012 for the following adult vaccine categories:

  • Influenza Vaccines
  • Hepatitis Vaccines
  • Pneumococcal Vaccines
  • Travel, DT and other Adult Vaccines
  • Cervical Cancer
This is a rapidly changing marketplace and knowledge of the R&D pipeline is essential to truly understand what is happening in vaccines. Vaccines in development are discussed in this report, including vaccines for the following conditions:
  • Enterotoxigenic Escherichia coli
  • Parainfluenza Virus Type 3
  • Pneumococcal Vaccines
  • Respiratory Syncytial Virus<
  • Cancers
  • Cholera
  • HIV/AIDS
  • Helicobacter Pylori
  • Malaria
  • Rabies
  • Tuberculosis
  • West Nile Virus
This Kalorama Information report was created with a primary research effort - interviews with market experts in the vaccine market who shared insights, informed of new trends and helped to construct models, supplemented by secondary research in company, medical and trade literature. Marketing and Business Development executives, strategic planners, research and development executives, as well as investors and financial consultants are among those who will find this a useful resource.
CHAPTER ONE: EXECUTIVE SUMMARY
The Global Vaccine Industry
Scope And Methodology
Overview
Pediatric Preventative Vaccines
The Market
Adult Preventative Vaccines
The Market
Total Vaccine Market
Issues and Trends
A “Gardasil Effect” in R&D?


CHAPTER TWO: INTRODUCTION TO VACCINES
A Brief History: The Development of Vaccines
The Immune Response
Mechanism of Action
Types of Vaccines
Attenuated (Weakened) Live Viruses
Killed (Inactivated) Viruses
Toxoid Vaccines
Genetically Engineered/Modified Vaccines
Subunit Vaccines
Conjugate Vaccines
DNA Vaccination
Vaccine Approval Process


CHAPTER THREE: PEDIATRIC VACCINES
Introduction
Childhood Immunization in the United States
Childhood Immunization Rates
Challenges to the Vaccine Delivery System
Recommended Childhood Immunization Schedule
State Immunization Recommendations
Pediatric Vaccine Products
BCG Vaccines
Diphtheria, Tetanus, Pertussis, Hepatitis B and Polio Vaccines
Diphtheria
Pertussis
Tetanus
Hepatitis B
Poliomyelitis
Haemophilus Influenzae Type B Vaccines
Hepatitis A Vaccines
Measles, Mumps and Rubella Vaccines
Measles
Mumps
Rubella
Pneumococcal Conjugate Vaccine
Rotavirus Vaccines
Varicella Vaccines
Meningococcal Vaccines
Cost of Vaccines in the United States
Pediatric Vaccines in Development
Global Initiatives for Vaccine Research
Enterotoxigenic Escherichia coli
Parainfluenza Virus Type 3
Pneumococcal Vaccines
Respiratory Syncytial Virus
The World Market for Pediatric Preventive Vaccines
Total Market Size and Forecast
DTP and DTaP Vaccine Market
Market Analysis
Leading Products and Competitors
Hepatitis Vaccine Market
Market Analysis
Leading Products and Competitors
Haemophilus Influenzae Type B Vaccine Market
Market Analysis
Leading Products and Competitors
Measles, Mumps and Rubella Vaccines
Market Analysis
Combination Vaccines Market
Market Analysis
Leading Products and Competitors
Pneumococcal Vaccine
Leading Products and Competitors
Poliovirus Vaccine
Market Analysis
Leading Products and Competitors
Varicella Vaccines
Market Analysis
Leading Products and Competitors
Other Vaccines Market
Market Analysis
Leading Products and Competitors


CHAPTER FOUR: ADULT PREVENTIVE VACCINES
Introduction
Adult Vaccine-Preventable Diseases: Facts and Figures
Global Virological Surveillance Program
Recommendations for Adult Immunizations
WHO International Health Regulations
Adult Vaccine Products
BCG Vaccines
Cervical Cancer Vaccines
Cholera Vaccines
Diphtheria-Tetanus Vaccines
Hepatitis Vaccines
Hepatitis A
Hepatitis B
Influenza Vaccines
Japanese Encephalitis Vaccines
Pneumococcal Disease Vaccines
Rabies Vaccines
Shingles Vaccine
Typhoid Vaccines
Yellow Fever Vaccines
Adult Vaccines in Development
Global Initiatives for Vaccine Research
Cancer
Cholera
HIV/AIDS
Helicobacter Pylori
Hepatitis
Hepatitis B
Hepatitis C
Hepatitis E
Herpesvirus
Influenza
Leishmaniasis
Malaria
Rabies
Tuberculosis
Typhoid Fever
West Nile Virus
The World Market for Adult Preventive Vaccines
Total Market Size and Forecast
Cervical Cancer Market
Market Analysis
Leading Products and Competitors
Hepatitis Market
Market Analysis
Leading Products and Competitors
Influenza Vaccine Market
Market Analysis
Leading Products and Competitors
Market Analysis
Leading Products and Competitors
Travel, DT, and Miscellaneous Vaccine Market
Market Analysis
Leading Products and Competitors


CHAPTER FIVE: VACCINES MARKET SUMMARY
Trends Driving the Vaccines Market
Market Size and Forecast
Vaccine Market Competitors
Pediatric Vaccines
Major Manufacturer’s Market Share
Adult Vaccines
Major Manufacturer’s Market Share


CHAPTER SIX: ISSUES AND TRENDS
Resistance to Immunization
Vaccine Safety
Vaccine Adverse Event Reporting System
The Vaccine Safety Datalink Project
The Vaccine Injury Compensation Program
Increased US Vaccine Availability
Vaccine Shortages
Preventing Shortages in the Developed Countries
A 'Gardasil Effect' in R&D?
Vaccines and Bioterrorism
Overview
Project Bioshield Act of 2004
National Bio and Agro-Defense Facility
Vaccine Treatment and Evaluation Units
Anthrax
Smallpox
Plague
Botulism
Tularemia
Viral Hemorrhagic Fevers
DNA Vaccination
Innovations in Vaccine Delivery Systems
Edible Vaccines
Mucosal Delivery
Intranasal Delivery
Oral Vaccines
Vaccine Patches


CHAPTER SEVEN: COMPANY PROFILES
Acambis plc
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
AlphaVax, Inc.
History and Lines of Business
Strategic Alliances
Vaccine Products
Avant Immunotherapeutics
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Bavarian Nordic A/S
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Baxter Healthcare
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Crucell
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Emergent biosolutions
History and Lines of Business
Strategic Acquisition and Alliance
Vaccine Products
Financial
GlaxoSmithKline
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Medimmune
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Merck & Co. Inc
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Nabi Biopharmaceuticals
History and Lines of Business
Strategic Alliance
Vaccine Products
Financial Information
Novartis
History and Lines of Business
Strategic Alliances
Vaccine Products
Pfizer
History and Lines of Business
Strategic alliances
Vaccine products
Financial Information
Pharmexa
History and Lines of Business
Strategic alliances
Vaccine Products
Financial Information
Sanofi Pasteur
History and Lines of Business
Strategic Alliances
Vaccine Products
Financial Information
Wyeth
History and Lines of Business
Vaccine Products
Financial Information


APPENDIX: COMPANY DIRECTORY


TABLE OF EXHIBITS


CHAPTER ONE: EXECUTIVE SUMMARY
Figure 1-1: World Market for Pediatric Vaccines 2004-2013 Revenues
Figure 1-2: World Market for Adult Vaccines 2004-2013 Revenues


CHAPTER TWO: INTRODUCTION TO VACCINES
Table 2-1: Impact of Vaccines in the 20th Century Annual Morbidity in the 20th Century vs 2006
Table 2-2: Vaccine-Preventable Diseases, April 2008


CHAPTER THREE: PEDIATRIC PREVENTIVE VACCINES
Table 3-1: Global Immunization Rates by Vaccine Type 2006
Table 3-2: Immunization Profile of the United States: Population by Age Group, Number of Vaccine-Preventable Diseases Reported by Disease 2000-2006
Table 3-3: U.S. Recommended Childhood Immunization Schedule, 2008
Table 3-4: U.S. Recommended Adolescent Immunization Schedule, 2008
Table 3-5: Selected Pediatric Vaccines in Development, April 2008
Table 3-6: World Market for Pediatric Vaccines by Type (DTaP/DTP, Hep, HiB, MMR, Combos, Pneumococcal, Polio, Varicella, Others) 2004-2013
Figure 3-1: Market Share of Pediatric Vaccines by Type 2007
Figure 3-2: Market Share of Pediatric Vaccines, by Type 2013
Table 3-7: World DTP and DTaP Vaccine Market 2004-2013
Table 3-8: World Pediatric Hepatitis Vaccine Market 2004-2013
Table 3-9: World Hib Vaccine Market, 2004-2013
Table 3-10: World MMR Vaccines Market 2004-2013
Table 3-11: World Combination Vaccines Market 2004-2013
Table 3-12: World Pediatric Pneumococcal Vaccine Market 2004-2013
Table 3-13: World Poliovirus Vaccine Market 2004-2013
Table 3-14: World Varicella Vaccine Market 2004-2013
Table 3-15: Other Vaccines Market 2004-2013


CHAPTER FOUR: ADULT PREVENTIVE VACCINES
Table 4-1: Universal Adult Immunization Schedule 2008
Table 4-2: Adult Immunization Schedule for Populations with Special Medical Conditions, 2008
Table 4-3: Initiatives to Require HPV Vaccination by U.S. State, 2008
Table 4-4: Selected Adult Preventive Vaccines in Development, 2008
Table 4-5: World Market for Adult Preventive Vaccines by Type (Hepatitis, Influenza, Pneumococcal, Travel/DT/Misc.), 2004-2013
Figure 4-1: Market Share of Adult Vaccines, by Type, 2007 (Cervical Cancer, Hepatitis, Influenza, Pneumococcal, Travel)
Figure 4-2: Market Share of Adult Vaccines, by Type, 2013
Table 4-6: World Cervical CancerVaccine Market 2004-2013
Table 4-7: World Hepatitis Vaccine Market 2004-2014
Table 4-8: World Influenza Vaccine Market 2004-2013
Table 4-9: CDC Goal to Double Flu Immunization by 2010 Group and Estimated Immunization Rate (2000 vs 2010)
Table 4-10: 2007 Estimated Population by Region and Selected Age Group
Table 4-11: World Pneumococcal Vaccine Market 2004-2013
Table 4-12: World Travel; Diphtheria-Tetanus; Miscellaneous Vaccines Market 2004-2013


CHAPTER FIVE: VACCINES MARKET SUMMARY
Table 5-1: The World Vaccines Market by Vaccine Type 2004-2013
Figure 5-1: World Market for Vaccines by Type 2004-2013
Figure 5-2: World Market for Vaccines Share by Type, 2004, 2007 and 2013
Table 5-2: Major Manufacturers’ Shares of the World Vaccine Market, 2007 154 Figure 5-3: 2007 World Vaccines Market Share, by Leading Competitors 155 Table 5-3: Major Manufacturer’s Shares of the World Pediatric Vaccine Market 2007
Figure 5-5: Market Share of Pediatric Vaccines Market, 2007 157 Table 5-4: Major Manufacturer’s Shares of the World Adult Vaccine Market 2007
Figure 5-6: Market Share of Adult Vaccines Market 2007


CHAPTER SIX: ISSUES AND TRENDS
Table 6-1: Selected Companies/Laboratories Developing Biodefense Vaccines

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