DNA Sequencing Markets (Next-Generation Systems, Capillary Systems, Consumables, Services)

Sep 7, 2012
180 Pages - Pub ID: KLI4871738
Attention: There is an updated edition available for this report.
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TABLE OF CONTENTS

CHAPTER ONE: EXECUTIVE SUMMARY

  • Introduction
    • New Systems, Services Create Uncertainty
    • A Period of Rapid Adoption, But Lower Prices
    • Further Longer-Term Challenges
    • Rapid Growth Overall, But Intense Competition
    • Customers’ Research Models Evolving
    • Established Next-Generation Systems Seeing Slowdown
  • Background
    • Scope and Methodology
    • Applications and Definitions
    • Types of Samples
    • DNA Sequencing Strategies
CHAPTER TWO: SEQUENCER MARKET TRENDS
  • Industry and Technology Trends
    • Market Fragmenting Into Multiple Product Types and Applications
    • Continual Improvements Expand Sequencer Market
    • Acquisitions and Collaborations for New Technologies
    • Patent Infringement, Other Legal Disputes
    • Slow Path to Potentially Large Clinical Markets
    • Spread of Targeted Enrichment, Sequence-Capture Products and Services
    • Synergies Appearing Between Life Science Companies’ Products
    • Consumer Genomics, Genetic Testing, Pharmacogenetics Still Entering Mainstream
  • NHGRI Funding, Budget, Periodic Strategic Planning
    • NHGRI Shifts Funds from Centralized Sequencing Centers
    • NHGRI White Paper #4: The Future of Genome Sequencing
  • Genome Projects and Consortia
    • The Cancer Genome Atlas (TCGA) Project
    • National Plant Genome Initiative
    • NSF/USDA Microbial Genome Sequencing Program
CHAPTER THREE: DNA SEQUENCING SYSTEMS AND TECHNOLOGIES
  • 454 Life Sciences (Roche)
    • Genome Sequencer FLX, FLX+, Junior
    • Illumina
      • HiSeq, HiScan SQ, MiSeq, Genome Analyzer IIx
      • Intelligent Biosystems (Qiagen)/Azco Biotech
      • LI-COR Biosciences 4300
      • Life Technologies/Applied Biosystems
      • ABI Prism 310 Genetic Analyzer
      • ABI Prism 3100-Avant Genetic Analyzer
        • Applied Biosystems 3100 Genetic Analyzer
        • Applied Biosystems 3130 Genetic Analyzer
        • Applied Biosystems 3130xl Genetic Analyzer
        • Applied Biosystems 3500 Genetic Analyzer
        • Applied Biosystems 3730 DNA Analyzer
        • Applied Biosystems 3730xl DNA Analyzer
        • ABI SOLiD 4, 5500, 5500xl, 5500xl W Genetic Analyzers
        • Ion Torrent Personal Genome Machine (PGM)
      • Pacific Biosciences
        • PacBio RS
      • Technologies Under Development
        • Introduction
        • Human Microbiome Project Technology Development Awards
CHAPTER FOUR: SEQUENCING MARKET ANALYSIS
  • Revenues Forecast
  • Historical Revenues
  • Overall Market Forecast
  • Sequencing For a Clinical Purpose
    • Roche
    • ABI
    • Illumina
    • Affymetrix
    • B.C. Cancer Agency
    • Emory Genetics Lab
    • Bacterial and Viral Applications for NGS
    • eGenomics
    • BGI
    • Pacific Biosciences
    • Clinical Sequencing vs. Research Sequencing Markets
CHAPTER FIVE: COMPETITIVE ANALYSIS
  • Introduction
    • Benchtop and Third-Generation Sequencers Bring Instability
    • Second-, Third-Generation Battle Still Undefined, Unresolved
    • Increased Flexibility with Purchasing
    • ABI Capillary Electrophoresis Holds Onto Large Segment
  • DNA Sequencer Market Shares
    • Smaller Companies Experiencing Struggles
  • Features and Strengths of Second-Generation Sequencers
    • 454 Life Sciences GS FLX–Strengths/Advantages
    • 454 Life Sciences GS FLX–Weaknesses/Disadvantages
    • 454 Life Sciences GS Junior–Strengths/Advantages
    • 454 Life Sciences GS Junior–Weaknesses/Disadvantages
    • Applied Biosystems SOLiD–Strength/Advantages
    • Applied Biosystems SOLiD–Weaknesses/Disadvantages
    • Illumina HiSeq/HiScan SQ–Strength/Advantages
    • Illumina HiSeq/HiScan SQ–Weaknesses/Disadvantages
    • Illumina MiSeq - Strength/Advantages
    • Illumina MiSeq-Weaknesses/Disadvantages
    • Life Technologies PGM-Weaknesses/Disadvantages
    • Pacific Biosciences PacBio RS-Strength/Advantages
    • Pacific Biosciences PacBio RS-Weaknesses/Disadvantages
CHAPTER SIX: INTELLECTUAL PROPERTY AND LITIGATION
  • Developments
    • Helicos’ Patent Infringement Suit Against PacBio, Life Technologies, and Illumina
    • Intelligent Bio-Systems and Columbia University Sue Illumina for Infringement
    • Illumina’s Two Lawsuits Against Complete Genomics for Infringement
    • Illumina Sues Life Technologies Over Ion Torrent Systems
    • Class Action Shareholder Lawsuit Filed Against Pacific Biosciences
    • Affymetrix Dismisses Suit Against Pacific Biosciences and Former Employees
    • Life Technologies Defeats VisiGen Stakeholders After Arbitration
    • Catalyst Assets Sues Life Technologies for Infringement
    • Patent Interference Between Life Technologies and Pacific Biosciences
    • Life Technologies and Illumina Dispute Over Amplification on Solid Surfaces
    • LadaTech Sues Illumina Over DNA Amplification Patent
    • Illumina Files ‘841 Patent Infringement Suit Against Affymetrix
    • Affymetrix and Illumina Settle Case Over ‘243, ‘432, ‘531, ‘365, and ‘716
    • Applied Biosystems and Illumina Claims and Counter-claims Over Sequencing-by-Ligation Both Unsuccessful
    • Fluidigm and Applied Biosystems Agree to End Case
    • Beckman Coulter and Applied Biosystems Settle Outstanding Legal Disputes
    • Cepheid and Idaho Technology Settle Dispute Over PCR Patents
    • Enzo Biochem Disputes CalTech Sequencing Patents
    • Huang v. CalTech
    • Applied Biosystems and Amersham plc (GE Healthcare) Settle Sequencing Patent Litigation
    • Early ABI (Life Technologies) Patents
CHAPTER SEVEN: DEALS
  • List of Deals in the Sequencing Industry
CHAPTER EIGHT: CORPORATE PROFILES
  • 454 Life Sciences (Roche)
  • Complete Genomics
  • Illumina
  • Life Technologies
  • Pacific Biosciences
CHAPTER NINE: CHALLENGES AND STRATEGIC RECOMMENDATIONS
  • Market Challenges
    • Fragmentation of Market Complicates Competition
    • and several others....
  • Strategic Recommendations
    • Intense Competition Requires Constant Innovation
    • and several others...

LIST OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

  • Figure 1-1: DNA Sequencer Revenues, 2001-2011
CHAPTER TWO: SEQUENCER MARKET TRENDS
  • Table 2-1: NHGRI Budget by Year Including ARRA Supplement, 2006-2012
  • Figure 2-1: NHGRI Budget including ARRA (2006-2012)
  • Table 2-2: Est. NHGRI Budget by Mechanism, 2012 ($M)
  • Figure 2-2: NHGRI Budget
  • Table 2-3: NHGRI Budget by Activity, 2010-2012 ($thou)
  • Figure 2-3: NHGRI Budget by Activity, 2012
  • Table 2-4: NHGRI Funding, Large-Scale Sequencing Centers ‘07&’12
  • Figure 2-4: NHGRI Funding, Large-Scale Sequencing Centers ‘07&’12
  • Table 2-5: NHGRI Funding, Centers for Mendelian Genomics, 2012
  • Figure 2-5: NHGRI Funding, Centers for Mendelian Genomics, 2012
  • Table 2-6: NHGRI Clinical Sequencing Exploratory Research Awards, 2012
  • Table 2-7: Fuge Funding Recipients
  • Table 2-8: Plant Genome Comparative Sequencing Program (PGCSP) Awards, FY 2011
  • Table 2-9: NSF / USDA Microbial Genome Sequencing Program Awards, 2008-2011
  • Table 2-10 Other Initiatives and Consortia Using DNA Sequencing, 2012
CHAPTER THREE: DNA SEQUENCING SYSTEMS AND TECHNOLOGIES
  • Table 3-1: DNA Sequencer Products/ Technologies, 2012
  • Table 3-2: NIH Human Microbiome Project Technology Dev’t Awards, 2010
  • Table 3-3: NHGRI $1,000 Genome Grant Awards, 2009
  • Table 3-4: NHGRI $1,000 Genome Grant Awards, 2010
  • Table 3-5: NHGRI $1,000 Genome Grant Awards, 2011
  • Table 3-6: NHGRI Advanced Sequencing Technology Awardees, 2009
  • Table 3-7: NHGRI Medical Sequencing Discovery Awards, 2009
  • Table 3-8: NHGRI Understanding Genome Function Awards, 2009
  • Table 3-9: NHGRI Population Genomics Awards, 2009
  • Table 3-10: NHGRI Advanced Sequencing Technology Awardees, 2009
  • Table 3-11: Other Initiatives and Consortia Supporting Technology Development, 2012
CHAPTER FOUR: SEQUENCING MARKET ANALYSIS
  • Figure 4-1: Cost of Sequencing a Genome
  • Table 4-1: Market Forecast by Segment (Systems, Consumables, Services) , 2011-2016
  • Table 4-2: Sequencing Market Revenues Growth Rates by Segment, 2011-2016 (Systems, Consumables, Services)
  • Table 4-3: Sequencer Equipment Market, 2001-2011 ($M)
  • Table 4-4: Growth Rates, Sequencer Equipment Market, 2001-2011 ($M)
  • Figure 4-3: Sequencer Equipment Market, 2001-2011 ($M)
  • Figure 4-4: ABI Sequencing Revenues, Q3 2001 – Q3 2008
  • Figure 4-5: ABI Sequencing Revenues, Focus on Q4 2004 – Q3 2008
  • Figure 4-6: DNA Sequencer Market Forecast, 2011-2016:
  • Figure 4-7: Breakout of DNA Sequencing Market by Application(Clinical vs. Research) 2011
  • Figure 4-8: Breakout of DNA Sequencing Market by Application(Clinical vs. Research) 2016
CHAPTER FIVE: COMPETITIVE ANALYSIS
  • Table 5-1: DNA Sequencer Market Shares
  • Figure 5-1: DNA Sequencer Market Shares
  • Figure 5-2: Pacific Biosciences Quarterly Revenues, 2011-2012 ($M)
  • Figure 5-3: Complete Genomics Quarterly Revenues, 2010-2012 ($M)
  • Table 5-2 Comparison of Sequencers’ Performance, mid-2012
CHAPTER SIX: INTELLECTUAL PROPERTY AND LITIGATION
  • Table 6-1: Patents
CHAPTER SEVEN: DEALS
  • Table 7-1: Deals in the Sequencer Market
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