• Introductions
• Scope and Methodology
• Summary of Major Findings

Chapter Two: Prion Disease Primer

• Introduction
• Human Prion Diseases
• Variant Creutzfeldt-Jakob disease (vCJD)
• Gertsmann-Straussler-Scheinker (GSS) Syndrome
• Fatal Familial Insomnia (FFI)
• Kuru
• Animal Prion Disease
• Scrapie
• Bovine Spongiform Encephalopathy (BSE)
• Chronic Wasting Disease (CWD)
• Feline Spongiform Encephalopathy (FSE)
• Tranmissible Mink Encephalopathy (TME)
• Exotic Ungulate Encephalopathy

Chapter Three: The Technologies

• Prion Diagnostic Technology Definitions
• Polymerase Chain Reaction
• Synthetic Ligands
• Electrocardiogram (ECG)
• Immunoassays
• Nucleic Acid Hybridization
• Protein Misfolding Cyclic Amplifications (PMCA)
• Aptamer
• Capillary Electrophoresis and Chromatography
• Membrane-Based Preparative Electrophoresis
• Biomarkers
• Transgenic Mice
• Prion Diagnostic Competitors and Products
• Post-Mortem BSE Testing
• Post-Mortem Scrapie Prion Diagnostics
• Post-Mortem CWD Prion Diagnostics
• Ante-Mortem Prion Diagnostic Technology
• Ante-Mortem BSE Prion Diagnostic Technologies
• Ante-Mortem Scrapie Prion Diagnostics
• Ante-Mortem vCJD Prion
• Ante-Mortem CWD Prion Diagnostic Technologies

Chapter Four: The Markets

• Total TSE Post-Mortem Diagnostic Testing
• Post-Mortem BSE Cattle Testing
• Post-Mortem Scrapie Sheep (Ovine) Testing
• Post-Mortem Scrapie Caprine (Goat) Testing
• Post-Mortem CWD Testing
• Total Market
• CWD Testing in Wild and Captive Deer
• Ante-Mortem TSE Diagnostic Testing
• Emerging Markets
• Worldwide Sheep Genotyping
• Species Identification
• Prion Removal Techniques

Chapter Five: Conclusions and Strategic Implications

• First Conclusion
• Second Conclusion
• Third Conclusion
• Fourth Conclusion

Chapter Six: Company Profiles

• Abbott Laboratories
• Altegen, Inc.
• BIORAD
• Biotraces, Inc.
• Caprion Pharmaceuticals, Inc.
• Chronix Biomedical
• Gene Thera
• Gradipore Inc.
• Idexx Laboratories
• InPro Biotechnology
• InPro Biotechnology
• Microsens Biotechnologies
• Ortho-Clinical Diagnostics/Johnson & Johnson
• Prion Developmental Laboratories
• Prionics AG
• PrioSense Ltd.
• ProMetic Life Sciences
• Proteome Sciences plc
• Serono Pharmaceutical Research Institute
• TSEnse Diagnostics Ltd
• VMRD, Inc.

APPENDIX: Company Directory
List of Exhibits
Chapter Two: Prion Disease PrimeR

• Table 2-1: Number of Confirmed BSE Cases in Countries around the World
• Table 2-2: Number of CWD Affected Herds in North America by
• State or Province 2003
• Table 2-3: Summary of Prion Diseases, Hosts and Mechanism

Chapter Three: The Technologies

• Table 3-1: Number of Current Prion Diagnostic Competitors by Country
• Ante- and Post-Mortem 2003
• Table 3-2: Ante-Mortem & Post-Mortem Prion Diagnostic Companies
• Table 3-3: Ante- & Post-Mortem Prion Diagnostic Test by Technology and
• Number of Companies
• Table 3-4: Post-Mortem Prion Diagnostics by Companies and Technologies
• Table 3-5: Post-Mortem BSE Prion Diagnostic Test Technologies
• Table 3-6: Summary of Post-Mortem BSE Diagnostics on the Market or in Development
• Table 3-7: Post-Mortem Scrapie Prion Diagnostic Technologies
• Table 3-8: Summary of Post-Mortem Scrapie Diagnostics on the Market or in Development
• Table 3-9: Post-Mortem CWD Prion Diagnostic Technologies
• Table 3-10: Summary of Post-Mortem CWD Diagnostics on the Market or in Development
• Table 3-11: Ante-Mortem Prion Diagnostic Companies and Technologies
• Table 3-12: Ante-Mortem BSE Prion Diagnostic Technologies
• Table 3-13: Summary of Ante-Mortem BSE Diagnostics on the Market or in Development
• Table 3-14: Ante-Mortem Scrapie Prion Diagnostic Technologies
• Table 3-15: Summary of Ante-Mortem Scrapie Diagnostics on the Market or in Development
• Table 3-16: Ante-Mortem vCJD Prion Diagnostic Technologies
• Table 3-17: Summary of Ante-Mortem vCJD Diagnostics on the Market or in Development
• Table 3-18: Ante-Mortem CWD Prion Diagnostic Technologies

Chapter Four: The Markets

• Table 4-1: Worldwide TSE Post-Mortem Diagnostic Testing Revenue 2001-2008
• Table 4-2: Worldwide TSE Post-Mortem Diagnostic Testing Volume 2001-2008
• Table 4-3: Worldwide BSE Cattle Testing Revenue by Geographic Regions 2001-2008
• Table 4-4: Worldwide Post-Mortem BSE Cattle Testing Volume by Geographic Regions 2001-2008
• Figure 4-2: Distribution of Post-Mortem BSE Tests by Geography 2003
• Table 4-5: European Union & Acceding/EEA Countries Passive BSE Testing Revenues 2001, 2002, and First Four Months of 2003
• Table 4-6: European Union & Acceding/EEA Countries Passive BSE Testing Volume 2001, 2002, and First Four Months of 2003
• Figure 4-3: Total European Passive BSE Testing Revenue Distribution by Country 2002
• Table 4-7: European Union & Acceding/EEA Total Active BSE Screening Revenues by Country 2001-2003
• Table 4-8: European Union & Acceding/EEA Total Active BSE Screening Testing Volumes by Country 2001-2003
• Figure 4-4: Total Active European Passive BSE Testing Revenue Distribution by Country 2003
• Table 4-9: European Union & Acceding/EEA Healthy Slaughter Active BSE Screening Revenues by Country 2001-2003
• Table 4-10: European Union & Acceding/EEA Healthy Slaughter Active BSE Screening Testing Volume by Country 2001-2003
• Figure 4-5: Total European Healthy Slaughter Active BSE Screening Revenue Distribution by Country 2003
• Table 4-11: European Union & Acceding/EEA Other Active BSE Screening Revenue by Country 2001-2003
• Table 4-12: European Union & Acceding/EEA Other Active BSE Screening Testing Volume by Country 2001-2003
• Figure 4-6: Total European Other Active BSE Screening Distribution of Revenues by Country 2003
• Table 4-13: Worldwide Scrapie Sheep Testing Revenues by Geographic Region 2001-2008
• Table 4-14: Worldwide Scrapie Sheep Testing Volume by Geographic Region 2001-2008
• Table 4-15: Worldwide Scrapie Goat Post-Mortem Testing Revenue 2001-2008
• Table 4-16: Worldwide Scrapie Goat Post-Mortem Testing Volume 2001-2008
• Table 4-17: Worldwide CWD Post-Mortem Testing Revenues by Geographic Region 2001-2008
• Table 4-18: Worldwide CWD Post-Mortem Testing Volume by Geographic Region 2001-2008
• Table 4-19: CWD Post-Mortem Tests in the United States Revenues by Wild vs. Captive Deer 2001-2008
• Table 4-20: CWD Post-Mortem Tests in the United States Testing Volume by Wild vs. Captive Deer 2001-2008
• Table 4-21: CWD Post-Mortem Tests in Canada Revenues by Wild vs. Captive Deer 2001-2008
• Table 4-21: CWD Post-Mortem Tests in Canada Testing Volume by Wild vs. Captive Deer 2001-2008
• Table 4-25: Sheep Genotyping Testing Volume by Country