CHAPTER ONE: EXECUTIVE SUMMARY

• Applications and Industries
• Scope and Methodology

CHAPTER TWO: INTRODUCTION

• Background and Definitions
• Pumps
• Columns
• Detectors
• Other Accessories and Consumables
  • Applications and Industries
  • Scope and Methodology

CHAPTER THREE: MARKET TRENDS

• Collaborations, M&A Activity, Regional Expansion
• Rise of Diagnostics and Other Clinical Applications
• HPLC Spreading Into Niches in Clinical Labs
• Advantages and Disadvantages of LC-MS in Clinical Applications
• Detection of Doping Agents Using LC-MS
• Therapeutic Drug Monitoring of Fentanyl in Urine With LC-MS-MS
• Forensic Toxicology Using LC-MS-MS
• Discovery and Detection of Genetic Variation by DHPLC
• Measuring the Level of Vitamin D in Blood
• Increased Global Focus on Food Safety
  • Introduction
  • European Union Updates Maximum Residue Levels for Pesticides
  • Japan Establishes Positive List System
  • Melamine Contamination of Pet Foods and Dairy
  • FDA Publishes Laboratory Information Bulletin on Melamine, May 2007
  • FDA Publishes Laboratory Information Bulletin on Melamine, October 2008
  • Agilent Technologies Addresses Melamine in Food
• Green, Eco-friendly Trends Affecting LC Market
• Production Scale LC and Process Analytical LC Gaining Momentum
• LC, GC, SFC Applications Blurring
• Chiral Separations Gaining Importance
• FDA Issues Policy Statements on Chiral Drugs
• LC Products for Chiral Separations Proliferate
• Hydrophilic Interaction Chromatography (HILIC) Experiencing Rapid Growth
• Nano-LC and Nano-electrospray Find Strong Niche Markets
• Protein Analysis, Proteomics Driving Market
• UHPLC and Fast LC Technology
  • Shaking Up a Mature Market
  • Decreasing Particle Size and the van Deemter Curve
  • UHPLC and Fast LC Product Introductions Stimulate Market
  • Advances Create Market for New Parts, Consumables, Ancillary Products
• Alternative or Intermediate Forms of Fast, Faster LC
  • Using Standard Pressures for Fast LC
  • High Temperature LC
  • Particle Sizes of 2 um to 3 µm
  • Superficially Porous Particles
  • Optimizing Extra-Column Volume, Other Paramaters

CHAPTER FOUR: PRODUCTS

• Advanced Materials Technology, Inc.
  • Halo HPLC Columns
• Agilent Technologies
  • 1200 Series Rapid Resolution LC (RRLC)
  • HPLC-Chips
• Bio-Rad
• Eksigent Technologies
  • expressHT-Ultra
• ESA Biosciences
  • Corona Charged Aerosol Detector (CAD)
  • Coulochem and CoulArray Detectors
• Hitachi High Technologies
  • LaChromUltra
• Thermo Fisher Scientific
  • TurboFlow Columns
• Varian
  • 920-LC
• Waters
  • Acquity UPLC

CHAPTER FIVE: DEALS CHAPTER SIX: REVENUES FORECAST AND COMPETITIVE ANALYSIS

• Assumptions
• Competitive Analysis

CHAPTER SEVEN: CORPORATE PROFILES

• Agilent Technologies
• Bio-Rad
• Dionex
• Eksigent Technologies
• ESA Biosciences
• GE Healthcare
• Grace Davison Discovery Sciences (W.R. Grace & Co.)
• Hitachi High Technologies
• Proxeon Biosystems
• Shimadzu
• Thermo Fisher Scientific
• Varian
• Waters Corp.

CHAPTER EIGHT: CHALLENGES AND STRATEGIC RECOMMENDATIONS

• Challenges
  • Advances in Competing Technologies Erode Growth
  • Clinical Applications Require Adjustment for Companies
  • Diminishing Returns in Ultra and Fast LC Technologies
  • Precedence in Purchasing Decisions
  • Routine Applications Demand Different Types of Systems
  • Customers’ Experiencing Budget Restrictions or Flat Funding
  • Customers’ Uncertainty Regarding UHPLC and Fast LC
• Strategic Recommendations
  • Position for Shift Towards Protein Therapeutics
  • Expand into Related Applications and Products
  • Incorporate or Enable Green Features
  • Address Broader Mass Spectometry Adoption
  • Target Niche Applications Through Differentiation of Products
  • Strengthen and Emphasize Service and Support
  • Increase User-Friendliness and Standardization of Software

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

• Table 1-1: Factors Driving Green Initiatives at Labs(Factor, Percent of Respondents)

• Figure 1-2: Factors Driving Green Initiatives at Labs (Factor, Percent of Respondents)

CHAPTER THREE: MARKET TRENDS

• Table 3-1: Factors Driving Green Initiatives at Labs(Factor, Percent of Respondents)

• Figure 3-1: Factors Driving Green Initiatives at Labs (Factor, Percent of Respondents)

• Table 3-2: Nano-LC Systems, 2008 (Company, System)

• Table 3-3: UHPLC and Fast LC Systems along with Type of Technology and Pressure Limits

• Table 3-4: Columns with 2.0 and sub-2 um Totally Porous Particles, 2008

• Table 3-5: Columns Designed for High Temperature LC (HTLC)

• Table 3-6: Columns with 2 to 3 um Totally Porous Particles, 2008 (Company, Product, Base Material, Stationary Phases, Tmax (C))

• Table 3-7: Papers presented at HPLC 2007 and HPLC 2008

• Figure 3-2: Application Areas of Papers Presented at HPLC 2007 and 2008

• Table 3-8: Particle Size usage, 1997 & 2007

• Figure 3-3: Particle Size Usage, 1997 & 2007

• Table 3-9: Stationary Phase Used, 2008 (Stationary Phase, Percent of Labs)

• Figure 3-4: Stationary Phase Usage in HPLC, 2008 (Stationary Phase, Percent of Labs)

• Table 3-10: Stationary Phase Used in RP-HPLC, 2007 (Stationary Phase, Percent of Labs)

• Figure 3-4: Stationary Phase Used in Reverse-Phase HPLC, 2007 (Stationary Phase, Percent of Labs)

• Table 3-11: Analytical HPLC Mode and Stationary Phase Usage, 2007 (Stationary Phase, Percent of Labs)

• Figure 3-5: Analytical HPLC Mode and Stationary Phase Usage, 2007

• Table 3-12: Papers Presented at HPLC 2008

• Figure 3-6: Detection Techniques Used in Presentations at HPLC 2008

• Table 3-13: Number of Sample Injections During Column Life

• Figure 3-6: Average Number of Injections During Column Life, 1997 & 2007

• Table 3-14: Average Analytical Column Lifetime

• Figure 3-7: Average Analytical Column Lifetime, 1997 & 2007

• Table 3-15: Sources for HPLC Columns Purchase

• Figure 3-8: Sources for HPLC Columns Purchase, 1997 & 2007

• Figure 3-9: Top Factors When Selecting HPLC Column Supplier, 2007

• Table 3-16: Factors Driving Green Initiatives at Labs

• Figure 3-10: Factors Driving Green Initiatives at Laboratories

• Table 3-17: Column Developments of Interest in the Future

• Figure 3-11: Column Technology Developments of Interest in the Future, 2007

• Table 3-18: Anticipated Usage & Impact of UPLC/UHPLC in Next 5-8 Years, 2008

• Figure 3-12: Anticipated Usage and Impact of UPLC/UHPLC in Next 5-8 Years, 2008

CHAPTER FOUR: PRODUCTS

• Table 4-1: Pressure Necessary for the Halo Column to Achieve Needed Flow Rates

• Figure 4-1: The van Deemter Plot of the Fused Core Particles Compared to Other Particles

CHAPTER FIVE: DEALS

• Table 5-1 Deals (Company 1, Company 2, Date, Comments)

CHAPTER SIX: REVENUES FORECAST AND COMPETITIVE ANALYSIS

• Table 6-1: World LC Market, 2007-2013

• Figure 6-1: World Liquid Chromatorgraphy Market Revenues, 2007-2013

• Table 6-2: World Liquid Chromatorgraphy Market Revenues, (US, Europe, Asia, Rest of World), 2007-2013

• Figure 6-2: World Liquid Chromatorgraphy Market, Growth Rate, 2007-2013

• Table 6-3: Top Factors When Selecting HPLC Column Supplier, 2007

• Table 6-4: Market Shares of LC Suppliers, 2007

• Figure 6-3: Figure 6-3 Market Shares of LC Suppliers, 2007

• Figure 6-4: LC Revenues of Leading Suppliers, 2007

• Figure 6-5: Waters Corp. Revenues by Quarter, 2002 - 2008

• Figure 6-6: Waters Corp. Revenues by Region, 2002 & 2007