• Why Outsourcing?
  • Outsourcing in Drug Discovery: 2003 View
  • The Flat World of the 21st Century
  • India, Fiberoptics, and Y2K.
  • China, WTO & Japan.
  • Russia and Boeing.
  • VCs Promote Outsourcing.
  • Globalization in Drug Discovery: View in 2005
  
  
• Environment & Expectations
  • Wall Street’s View of CROs
  • Public Hot-Buttons
  • Strategic Questions
  • Future Expectations
  
  
• Report Objectives & Structure
• Results Summary
  • Observations on the Market
  • Key Issues & Answers
  • What are the factors shaping the drug discovery outsourcing market?
  • What are the major types of drug discovery services and which are growing fastest?
  • What are the implications of offshoring for this market?
  • What do customers look for in a supplier?
  • What do suppliers do to make themselves successful?
  • Who are the leaders in this market? Who are some promising newcomers?
  • How large is the market and how fast is it growing?

Chapter Two: Outsourcing Issues

• The Outsourcing Decision
  • Questions Company Must Answer
  • Decision Criteria:
  • Geographic Considerations
  • Overseas Advantages & Limitations
  • Advantages for U.S.-based CROs
  • Academic vs. Commercial CRO
  
  
• How to Select a CRO
  • Factors Driving the CRO Selection Decision:
  • Negotiating the Deal
  
  
• Working with Your CRO
  • Elements of the Contract
  • How to Help Your CRO and Head Off Problems
  • Effective Alliance Management
  • Measuring Effectiveness of a Deal
  • Examples of Successful Deals
    • Product Supply Contract
    • Fee-for-Service and Full-Time Equivalent (FTE)
    • Collaborative Research Agreement
    • Non-Exclusive Alliance
    • Exclusive Strategic Alliance

Chapter Three: Offshoring

• Overview
  • Viewpoints
  • Pharmas and Offshoring
  • The Draw of Asia Pacific for Big Pharma
    • India
    • China
    • Japan
  • Investing in Asia
  
  
• Russia & Eastern Europe
  • Why Russia?
  • ChemBridge
  • Chemical Diversity (ChemDiv)
  • Q&A on Russian CROs
    • What Is It Like in Moscow?
    • How Is Doing Business There?
    • What Are the Barriers to Integration?
    • What Are the Issues Regarding Language?
    • What Are the Relative Strengths of Russia, China, and India in Outsourcing?
  
  
• India
  • Opportunities in India
  • India’s IP and Regulatory Environment
  • Indian CROs
  • Bottom line
  • Clinical Trials in India
  
  
• China, Taiwan, Korea
  • China’s Advantages & Limitations
  • The Chinese Market
  • Shanghai Bio-Explorer Inc.
  • Invitrogen in China
  • Roche Sets up New R&D Center in Shanghai
  • TargeGen and Their WuXi Relationship
  • Taiwan and TaiGen
  • Korea and Crystal Genomics

Chapter Four: Outsourcing from the Customer Side

• Perspectives of Pharmas
  • Preclinical Outsourcing at Amgen
  • GlaxoSmithKline Outsources Early Drug Discovery
  • Merck Partners for New Research
  • Pfizer Sources Discovery Chemistry
  • Purdue Pharma’s Offshoring Experience
  • TargeGen: a Small Pharma’s View of Outsourcing
  
  
• What Customers Seek in a CRO
  • Selection Criteria
  • Keys to Outsourcing Success
  
  
• What Pharma Spends
  • What the Pharma Industry Spends on R&D
  • What Pharma Spends on Outsourcing
    • Manufacturing
    • Clinical & Pre-clinical Research
    • Clinical Trials
    • Drug Discovery

Chapter Five: Outsourcing from the Supplier Side

• Supplier Model
  • Albany’s Success Formula
  • J-Star’s On-Shore Advantage
  • Cyprotex Takes the Lead
  
  
• Pre-Pharma Model
  • Ricerca’s One-Stop-Shop
  • Pharmacopeia Reinvents Itself
  • MerLion Springs from Nature
  
  
• Partnering Model
  • FSMA Collaboration with deCODE Chemistry—Outsourcing It All
  • Building a Bridge to China
  • Medarex’ Rx for Success
  
  
• Successful Suppliers’ Strategies
  • What business are we in and what business do we want to be in?
  • How does my unique technology become a market opportunity?
  • What services will we provide?
  • How will we attract and sell customers?
  • What should we do to make sure the assignment is successful?

Chapter Six: Markets for Outsourcing Services

• Chemistry Services Markets
  • Chemistry Outsourcing Rationale
  • Types of Chemistry Services and Suppliers
  • Leading Suppliers
  • Market Size & Projected Growth
  
  
• Biology Services Markets
  • Rise of Biology Services
  • Types of Biology Services
  • Suppliers and Technologies
  • Market Size & Projected Growth
  
  
• Screening Services Markets
  • Role of Outsourcing in HTS
  • Screening Services
  • Screening Services Suppliers
  • Market Size & Growth
  
  
• Lead Optimization Services Markets
  • Early ADME/Tox
  • Compound Analogues and SAR
  • Lead-Opt Service Suppliers
  • Market Size & Growth

Chapter Seven: Supplier Profiles

• Overview
• Albany Molecular Research, Inc.
  • Company History & Structure
  • Financials
  • Drug Discovery Services
  • Outsourcing Relationships
  
  
• ASINEX
  • Company History & Focus
  • Services Provided
  • Step-by-Step drug discovery … the ASINEX way
  • Clients
  
  
• Bridge Pharmaceuticals
  • Concept
  • Company Overview
  • Future Expectations
  
  
• Cardinal Health PTS (formerly Magellan Laboratories)
  • Company History & Structure
  • Financials
  • Drug Discovery & Development Services
  • Strategic Relationships
  
  
• ChemBridge & CRL
  • Company Structure & Focus
  • Drug Discovery Products & Services
  • Outsourcing Relationships
  
  
• Charles River Laboratories
  • History & Focus
  • Financials
  • PreClinical Services
  
  
• Chembiotek Research International
  • Ownership & Focus
  • Chemistry & Biology Research Services
  
  
• Chemical Diversity
  • Company History & Focus
  • Drug Discovery Services
  • Customers
  
  
• ComGenex Inc.
  • Company History & Focus
  • Drug Discovery Services
  • Outsourcing Research Partners
  
  
• Cyprotex
  • Company History and Focus
  • Financials
  • Technologies and Services
  • Future
  
  
• deCODE Genetics
  • Company Focus & Objectives
  
  
• Discovery Partners International
  • Company History & Acquisitions
  • Financials
  • Drug Discovery Services
  • Outsourcing Partners
  
  
• Dr. Reddy’s
  • Company History & Structure
  • Financials
  • Business Segments
  • Custom Pharmaceutical Services
  • Future of CRS
  
  
• Evotec OAI
  • Company History & Structure
  • Financials
  • Drug Discovery Services
  • Outsourcing Partners
  
  
• GVK Biosciences
  • Corporate Overview
  • Research Services
  • GVK Future
  
  
• J-Star
  • Company and Focus
  • Projects and Services
  • Unique Expertise
  
  
• Johnson Matthey Pharma Services (formerly Pharm-Eco)
  • Company History & Focus
  • Financials
  • Drug Discovery Services
  
  
• Jubilant Organosys Ltd.
  • Jubilant Corporation
  • Jubilant Biosys
  • Jubilant Organosys
  • Future
  
  
• Key Organics
  • History & Focus
  • Businesses: Products & Services
  • Outsourcing Services
  • Company Advantages
  
  
• MDS Pharma Services
  • Company History & Structure
  • Financials
  • Drug Discovery Services
  • Overseas Initiatives
  • Outsourcing Research Partners
  
  
• Medarex, Inc.
  • Company Focus & Objectives
  • Financials
  • Drug Discovery Services
  • Outsourcing Research Partners
  
  
• Medicilon
  • Company & Focus
  • Drug Discovery and Development Services Provided
  
  
• MerLion Pharmaceuticals
  • Company Background & Objectives
  • Drug Discovery Services
  • Outsourcing Research Parnters
  
  
• NovaScreen
  • Company Focus
  • Contract Services
  • Caliper Acquires NovaScreen
  
  
• Pharmacopeia
  • Company History & Focus
  • Financials
  • Drug Discovery Services
  • Research Partners
  
  
• PharmaCore
  • Company Focus
  • Drug Discovery Services
  • Outsourcing Research Partners
  
  
• PPD, Inc.
  • Company Focus
  • Financials
  • Drug Discovery Services
  • Outsourcing Research Partners
  
  
• Ricerca Biosciences LLC
  • Company Focus
  • Outsourcing Services
  • Future
  
  
• Scynexis
  • Company Capabilities & Focus
  • Customers
  • Description of Services Offered
  • Future Looks Bright
  
  
• WuXi Pharma Tech
  • Background & Strategy
  • WuXi Range of Services
  • Customer Comments

Appendix: Company Directory

List of Exhibits

Chapter One: Executive Summary

• Table 1-1: Projected Revenues by Market Segment (Chemistry, Biology,
• Screening, Lead Optimization) 2005-2009 Table 1-2: Leading Suppliers by Market Segment

Chapter Two: Outsourcing Issues

• Table 2-1: CRO vs. Academia A Comparison of Potential Partners
• Table 2-2: Why Deals Succeed and Why Deals Fail Factors in Success, Reasons for Failure, and Alliance Outcome Stats

Chapter Three: Offshoring

• Table 3-1: Outsourcing in India vs. China (Market Opportunities, Business Issues, Scientist Issues)

Chapter Four: Outsourcing from the Customer Side

• Figure 4-1: GlaxoSmithKline Productivity/Cost Supplier Evaluation Matrix
• Table 4-1: Different Criteria in Pfizer’s API and Discovery Chemistry Sourcing Table 4-2: CRO Capabilities Checklist
• Table 4-3: CRO Sourcing Options in Chemistry
• Table 4-4: Dos and Don’ts for Suppliers
• Table 4-5: Pharma Industry R&D Expenditures In-House vs.
• Outsourced 1997, 2001, 2005, 2009
• Table 4-6: Outsourced Drug Discovery and Development Expenditures by Type (Discovery vs. Clinical Trials) 1997, 2001, 2005, 2009

Chapter Five: Outsourcing from the Supplier Side

• Table 5-1: Suppliers by Types of Services Provided Chemistry, Biology,
• Lead Opt, Full Service

Chapter Six: Markets for Outsourcing Services

• Table 6-1: Chemistry Services Market (Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market) 2005-2009
• Table 6-2: Sales by Chemistry Market Segment (Building Blocks, Compound Synthesis, Libraries, Process Research, and Other Services) 2005
• Table 6-3: Biology Services Market (Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market) 2005-2009
• Table 6-4: Sales by Biology Market Segment (Protein Expression, Structural Analysis, Target Validation, Pathways Analysis, and Other Services) 2005
• Table 6-5: Screening Services Market (Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market) 2005-2009
• Table 6-6: Sales by Screening Market Segment (Assay Development, Primary Screening, Secondary Screening) 2005
• Table 6-7: Lead Optimization Services Market (Revenues, Annual Growth, and Share of Outsourced Drug Discovery Market) 2005-2009
• Table 6-4: Sales by Lead Optimization Market Segment (Early ADMET, Create Analogues, Computational Support, and Other Services) 2005

Chapter Seven: Supplier Profiles

• Table 7-1: Growth and Profitability Characteristics of Selected Contract Drug Discovery Companies by Company Size
• Table 7-2: Summary of Suppliers Profiled (Location, Year Founded, Revenues, Services, Number of Employees, Number of Clients)
• Table 7-3: Charles River Laboratories Sales by Segment (Research Models & Service, Preclinical Services, Clinical Services) First 9 Months of 2005 and Change of 2004
• Table 7-4: Applications for Cyprotex’s Cloe in Various Stages of Discovery