TABLE OF CONTENTS CHAPTER ONE: EXECUTIVE SUMMARY

• Scope and Methodology
• Challenges Facing the Pharmaceutical Industry
• Meeting Investor Expectations
• Erosion of Blockbuster Sales
• Increased Generic Competition
• Pricing Pressures
• Pipeline Output Slowing Compared to ROI
• Strategies to address challenges
• Mergers and Acquisitions
• Strategic Outsourcing
• Outsourcing Manufacturing Operations
• Outsourcing Sales and Marketing
• Contract Manufacturing
• Biopharmaceutical Manufacturing
• Characteristics of Biopharmaceutical Manufacturing
• Biopharmaceutical Manufacturing Demand Increasing
• CMOs Expanding Operations to Manufacture Biologics
• Contract Primary Manufacturing
• Ramping up the Technology Toolbox to Gain a Competitive Edge
• Contract Primary Manufacturing Trends
• Secondary Contract Manufacturing
• Demand for Sterile Manufacturing Capabilities on Increase
• Contract Manufacturing Market Analysis
• Contract Sales and Marketing
• Contract Sales Organizations
• Drivers of Outsourcing Sales & Marketing
• CSOs Offer Broad-based Portfolio of Services
• Maximize Efficiency of Sales and Marketing
• Speed and Flexibility
• Provide Sales Team to Companies with No In-House Sales/Marketing Experience
• Contract Sales Market Analysis

CHAPTER TWO: MEETING THE CHALLENGES OF A CHANGING MARKETPLACE

• Challenges Facing the Pharmaceutical Industry
• Meeting Investor Expectations
• Erosion of Blockbuster Sales
• Increased Generic Competition
• Pricing Pressures
• Pipeline Output Slowing Compared to ROI
• Strategies to address challenges
• Mergers and Acquisitions
• Strategic Outsourcing
• Restructuring manufacturing operations
• Reducing the Size of In-house Sales Force

CHAPTER THREE: CONTRACT MANUFACTURING

• Industry Overview
• Major Drivers of Contract Manufacturing
• Key Competing Factors for Contract Manufacturing
• Biopharmaceutical Manufacturing
• Characteristics of Biopharmaceutical Manufacturing
• Types of Contractors Involved in Biomanufacturing
• Demand for Biopharmaceutical Manufacturing Increasing
• Impact of Financial Crisis on Biopharmaceutical Sector
• Production Capacity for Biopharmaceutical Manufacturing
• Alternative Methods of Producing Biopharmaceuticals
• CMOs Expanding Operations to Manufacture Biologics
• Biomanufacturing in Asia
• Contract primary manufacturing
• Contract Primary Manufacturing Trends
• Ramping up the Technology Toolbox to Gain a Competitive Edge
• Chiral Technologies
• Oligonucleotides and Peptides Capabilities
• Hi-Potency Capabilities
• Specialized Niches Offer Opportunity
• Dangerous Reagents
• Controlled Substances
• Exploring Other Growth Opportunities
• Contract Secondary Manufacturing
• Demand for Sterile Manufacturing Capabilities on Increase
• Market Analysis
• Contract Manufacturing Market and Forecast
• Mergers and Acquistions
• Contract Biomanufacturing
• Contract Biomanufacturing Market and Forecast
• Contract Secondary Manufacturing
• Biologics Drive Special Manufacturing Processes
• Ramping up Sterile Manufacturing
• Contract Secondary Manufacturing Market and Forecast
• Contract Primary Manufacturing
• Expanding into High Potency API Manufacturing
• Contract Primary Manufacturing Market and Forecast

CHAPTER FOUR: CONTRACT SALES AND MARKETING

• Contract Sales Organizations
• A Brief History of the CSO Industry
• Governmental and Organizational Regulations Impacting CSOs
  • Prescription Drug Marketing Act (PDMA)
  • Title 21 Code of Federal Regulations, Part 11 (21 CFR Part 11)
  • Office of Inspector General Guidelines (OIG) for Industry
  • Health Insurance Portability and Accountability Act (HIPAA)
  • Additional Guidelines Established by Industry and Professional Organizations
• Drivers of Outsourcing Sales & Marketing
• Broad-based Portfolio of Marketing and Sales Services
• Maximize Efficiency of Sales and Marketing
• Speed and Flexibility
• Provide Sales Team to Companies with No In-House Sales/Marketing Expertise
• Selecting A CSO
• Wide range of Services Offered by csoS
• Integrated Sales Force Recruitment, Training and Management
  • Implementation Services
  • Technical Support Service
  • Data Center Services
  • Call Center Services
  • Hardware Support Services
  • Training and Educational Services
• Product, Sample and Literature Fulfillment
• Telemarketing
• Brand/Portfolio Analytics and Forecasting
• Strategic and Tactical Planning
• Strategic Consulting
• CSO -client contracts
• Improving Sales Force Effectiveness Through Technology-Based Solutions
• E-detailing
  • Virtual Live e-Detailing
  • Scripted e-Detailing
  • Physician Portal e-Detail
• Customer Relationship Management
• Mobile Technology
• Outsourcing CRM-related Services
• Information Management
• Business Intelligence & Analytics
• Commercial Operations
• Market Analysis: Contract Sales and Marketing
• Industry Characteristics
• Market Environment
• CSO Market and Forecast
• CSO Market Share
• Strategies for Gaining Market Share
• Strategic Acquisitions to Gain Market Share

CHAPTER FIVE: CONTRACT MANUFACTURING ORGANIZATIONS

• AVECIA Group plc
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• BACHEM HOLDING AG
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• BAXTER PHARMA SOLUTIONS
  • History and Lines of Business
  • Contract Manufacturing Services
  • Proprietary Formulation Technologies
  • Financial Information
• BAYER PHARMACEUTICAL MANUFACTURING SERVICES
  • History and Lines of Business
  • Contract Manufacturing
  • Financial Information
• BEN VENUE LABORATORIES
  • History and Lines of Business
  • Contract Manufacturing Services
  • Development Services
  • Clinical Material Manufacturing and Commercial Production
  • International Services
• BOEHRINGER-INGELHEIM
  • History and Lines of Business
  • Contract Manufacturing
  • Primary Manufacturing
  • Biopharmaceutical Manufacturing
  • Mammalian Cell Culture
  • Microorganisms and Yeast Fermentation
  • Financial Information
• CAMBREX CORPORATION
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• CATALENT PHARMA SOLUTIONS
  • History and Lines of Business
  • Financial Information
• CELLTRION, INC
  • History and Lines of Business
  • Contract Manufacturing Services
  • Cell Culture & Harvesting
  • Purification and Downstream Processing
  • Quality Assurance/Quality Control and Product Characterization
  • Formulation and Finish
• CHESAPEAKE BIOLOGICAL LABORATORIES
  • History and Lines of Business
  • Contract Manufacturing Services Commercial: Experimental:
• COVIDIEN PHARMACEUTICAL OUTSOURCING
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• DIOSYNTH BIOTECHNOLOGY
  • History and Lines of Business
  • Contract Manufacturing Services
• DSM PHARMACEUTICALS, INC.
  • History and Lines of Business
  • Contract Manufacturing Services
• DOWPHARMA
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• GENZYME PHARMACEUTICALS
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• GIRINDUS AG
  • History and Lines of Business
  • Contract Manufacturing Services
• HOLLISTER-STIER LABORATORIES CONTRACT MANUFACTURING
  • History and Lines of Business
  • Contract Manufacturing Services
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• HYALURON, INC.
  • History and Lines of Business Contract Manufacturing
• LAUREATE PHARMA
  • History and Lines of Business
  • Contract Manufacturing Services
• LONZA CUSTOM MANUFACTURING
  • History and Lines of Business
  • Contract Manufacturing Services: Lonza Biologics
  • Fermentation
  • High Yielding Cell Line
  • Purification
  • Choice of Chromatography Steps
  • Process Scale-Up
  • Process Validation
  • Process Transfer
  • Analytical Services
  • Development of Contaminant Assays
  • Product Characterization
  • Pre-formulation and Stability Studies
  • Analytical Support
  • Molecular Biology
  • Financial Information
• PATHEON, INC.
  • History and Lines of Business
  • Contract Manufacturing Services
  • Financial Information
• SIEGFRIED, INC.
  • History and Lines of Business
  • Contract Manufacturing Services
  • Accounting Information

CHAPTER SIX: CONTRACT SALES AND MARKETING COMPANY PROFILES

• ASHFIELD IN2FOCUS LIMITED
  • History and Lines of Business
  • Contract Sales Services
  • Dedicated Sales Teams
  • Hotspot Teams
  • Vacancy Management
  • Co-Funded Teams
• CEGEDIM DENDRITE
  • History and Lines of Business
  • Contract Sales & Marketing Services
  • Sales Solutions
  • Marketing Solutions Regulatory Compliance Clinical Solutions
  • Financial Information
• INNOVEX, Inc.
  • History and Lines of Business
  • Contract Sales and Marketing Services
• INVENTIV HEALTH, INC.
  • History and Lines of Business
  • Contract Sales, Marketing and Communication Services
  • inVentiv Clinical
  • inVentiv Communications
  • inVentiv Commercial
  • inVentiv Patient Outcomes
  • Financial Information
• ONCALL, LLC
  • History and Lines of Business
  • Contract Sales Services
  • Dedicated Field Sales Teams
  • Shared Field Sales Teams - OnCall-Share
  • Medical Scientific Liaison Services
  • Deployment options
  • Telesales
  • Marketing Services
• PROFESSIONAL DETAILING, INC.
  • History and Lines of Business
  • Contract Sales and Marketing Services
  • Contract Sales
  • Marketing Research
  • Medical Education and Communications
  • Financial Information
• VANGUARD PHARMA
  • History and Lines of Business
  • Contract Sales and Marketing
  • National Contract Sales Forces
  • Recruitment and Placement Services
  • New Product Launches Mature Product Support

APPENDIX: COMPANY NAMES AND ADDRESSES

TABLE OF EXHIBITS

CHAPTER ONE: EXECUTIVE SUMMARY

• Exhibit 1-1: Global Pharmaceutical Sales by Region, By Percent, 2007

CHAPTER TWO: MEETING THE CHALLENGES OF A CHANGING MARKETPLACE

• Exhibit 2-1: Global Pharmaceutical Sales by Region, 2007
• Exhibit 2-2: Global Research and Development Spending 2002-2012
• Exhibit 2-3: Drug Patent Expirations, 2007-2009
• Exhibit 2-4: NMEs and New BLAs Filed between 1996-2007

CHAPTER THREE: CONTRACT MANUFACTURING

• Exhibit 3-1: Selected Contract Manufacturing Subsidiaries of Pharmaceutical and Biotechnology Companies Competing in the Outsourcing Market
• Exhibit 3-2: Percent Of Respondents Projecting Production Increases Greater Than 100%by 2012
• Exhibit 3-3: Selected Top-selling Biopharmaceuticals, 2007
• Exhibit 3-4: Planned Future Capacity Expansions: 5-year Estimates, 2008 through 2012; Biotherapeutic Developers vs. CMOs
• Exhibit 3-5: Selected Animal-derived Biopharmaceuticals in Research and Development
• Exhibit 3-6: Selected Plant-made Biopharmaceuticals in Research and Development
• Exhibit 3-7: Selected CMO’S Expanding to Meet Biopharmaceutical Demand
• Exhibit 3-8: Selected Asia Biomanufacturing CMOs
• Exhibit 3-9: Global Prescription Pharmaceutical Contract Manufacturing Market Primary, Secondary and Biomanufacturing 2003-2013
• Exhibit 3-10: Selected Contract Manufacturing Mergers and Acquistions, 2007 & 2008
• Exhibit 3-11: Planned Future Capacity Expansions: 5-year Estimates, Biotherapeutic Developers vs. CMOs, 2008-2012
• Exhibit 3-12: Planned Future Capacity Expansions: 5-year Estimates, Biotherapeutic Developers vs. CMOS, 2008-2012
• Exhibit 3-13: Geographic Distribution of Contract Biopharmanufactures
• Exhibit 3-14: Global Contract Biomanufacturing Market, 2003-2013
• Exhibit 3-15: Global Secondary Contract Manufacturing Market, 2003-2013
• Exhibit 3-16: Global Contract Primary Manufacturing Market, 2003-2013

CHAPTER FOUR: CONTRACT SALES AND MARKETING

• Exhibit 4-1: Key Contract Sales Organization Solutions to Maximize ROI
• Exhibit 4-2: Global CSO Market
• Exhibit 4-3: CSO Market Share of Public Companies, 2007