Advances in Cancer Therapy

 
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Published Feb 1, 2001 | 394 Pages | Pub ID: KLI25

As we enter the 21st century, advances in the treatment of cancer will be significant and the patient will benefit in terms of quality of life. It is not unreasonable to anticipate a time when many cancer patients are managed as if they were chronically ill.

These thoughts are being shaped and driven by a variety of forces:

  • A new paradigm that would make use of the patient's natural immune and control systems
  • The vast array of developing knowledge in the area of cells
  • New products under development based on the immune system and cell function or death
  • Critical strategic alliances between researched-based pharmaceutical and biotech

This MarketResearch.com study focuses on the five key segments that will impact advanced cancer therapy:

  • Immunological and vaccine approaches
  • Antiproliferative approaches
  • Photodynamic therapy
  • Gene therapy approaches
  • Cell cycle and apoptosis approaches

The report provides detailed company profiles, which include:

  • Current products
  • Product pipeline
  • Key strategic alliances (large and small)
  • Discussions of the core technologies R&D activities

The study provides forecast information and examines selected dynamics and cancer statistics for the 7 major world markets.

Chapter One


    Executive Summary
    Introduction
    Scope And Methodology
    Size And Growth Of The Market
    Market Trends
    The Nature Of The Industry
    The New Technologies

Chapter Two


    Introduction
    • What Is Cancer?
    • Who Gets Cancer?

    Point Of View

Chapter Three


    Cancer Epidemiology
    Market Population Trends
    • Variations In Global Cancer Incidence

    Cancer Prevalence Trends
    Cancer Incidence Trends

Chapter Four


    Cancer Therapy Markets
    Market Overview
    • Antineoplastic Drugs
    • Cytotoxic Drugs
    • Hormonal Drugs
    • Adjunctive/Side-Effect Management Drugs
    • Hematopoietic Restoration
    • Severe Pain Management
    • Opportunistic Infection Control
    • International Market Overview

Chapter Five


    Current Therapeutic Approaches And Technology
    • How Cancer Is Treated
    • Sur
    • Laser Surgery
    • Electrosurgery
    • Cryosurgery
    • Radiation Therapy (Radiotherapy
    • External Radiation Therapy
    • Internal Radiation Therapy
    • Chemotherapy
    • Hormone Therapy
    • Biological Therapy

Chapter Six


    Advanced Cancer Therapeutics And The New Paradigm
    • The New Paradigm
    • Emerging Approaches To Cancer Therapy And Management: An Overview

Chapter Seven


    Immunological And Vaccine Approaches
    • The Technological Basis For Cancer Immunotherapy
    • Cytokine Therapeutics
    • Genetic Cytokine Stimulation
    • Cancer Vaccines
    • Modified Antibodies
    • Alternative Approaches To Cancer Immunotherapy
    • Progress In Cancer Immunotherapy
    • Limitations Of Immune Therapy
    • The Commercial Outlook

Chapter Eight


    Antiproliferative Approaches
    • Angiogenesis Regulators
    • Angiogenic Regulators In Tumor Vascularization
    • Progress In Angiogenesis Inhibitor Development
    • The Commercial Outlook

Chapter Nine


    Photodynamic Therapy
    • Mechanism Of Action
    • Photosensitizers
    • The Benefits And Limitations Of Pdt
    • Applications Of Pdt In Cancer
    • The Commercial Outlook

Chapter Ten


    Gene Therapy Approaches
    • Gene Therapy: Barriers And Drivers
    • The Technology Of Gene Therapy
    • Physical Gene Insertion Approaches
    • Direct Injection Of Genetic Material
    • Microprojectile Injection
    • Electroporation
    • Lithotriptic Shock Wave Insertion
    • Chemical Gene Insertion Approaches
    • Chemical Transfection
    • Lipofection
    • Cytofection
    • Liposomal Transfer
    • Biological Gene Insertion Approaches
    • Retrovirus Gene Vectors
    • Adenoviral Gene Vectors
    • Adeno-Associated Viruses (Aavs)
    • Herpesvirus Gene Vectors (Hsv-1)
    • Other Biological Vectors
    • Artificial Chromosome Gene Vectors
    • Ligand/Receptor Gene Vectors
    • Types And Effects Of Therapeutic Genes
    • Phenotype Alteration With Tumor Suppressor Genes
    • Phenotype Alteration With Oncogenes
    • Induction/Reduction Of Multidrug Resistance
    • Induction Of Cellular Toxicity By Gene Transfer
    • The Last Word In Gene Therapy
    • The Commercial Outlook

Chapter Eleven


    Cell Cycle And Apoptosis Approaches
    • Apoptosis
    • Inducing Apoptosis In Tumors
    • Cell Cycle-Based Cancer Therapeutics
    • The Commercial Outlook

Chapter Twelve


    Company Profiles
    Abgenix, Inc.
    Agouron Pharmaceuticals, Inc
    Amgen, Inc.
    Biomira, Inc.
    Bristol-Myers Squibb Co.
    British Biotech Plc
    Collagenex Pharmaceutics, Inc.
    Corixa, Corp.
    Dusa Pharmaceuticals, Inc.
    Genta, Inc.
    Genzyme Molecular Oncology
    Isis Pharmaceuticals, Inc.
    Morphosys Ag
    Onxy Pharmaceuticals, Inc
    Pharmacyclics, Inc
    Ribozyme Pharmaceuticals, Inc
    Sugen, Inc
    Vical, Inc.
    Competitive Summary

Chapter Thirteen


    Conclusions And Strategic Implications
    • First Conclusion
    • Implications
    • Second Conclusion
    • Implications
    • Third Conclusion
    • Implications
    • Fourth Conclusion
    • Implications
    • Fifth Conclusion
    • Implications
    • Sixth Conclusion
    • Implications
    • Seventh Conclusion
    • Implications
    • Eighth Conclusion
    • Implications
    • Ninth Conclusion
    • Implications
    • Tenth Conclusion
    • Implications
    • Eleventh Conclusion
    • Implications
    • Twelfth Conclusion
    • Implications
    • Thirteenth Conclusion
    • Implications
    • Fourteenth Conclusion
    • Implications

Appendix A


    Glossary

Appendix B


    Company Names And Addresses

List of Exhibits


    Chapter One: Executive Summary
    Table 1-1: The Size Of Cancer Therapeutic Markets In The Seven Major World Healthcare Markets: 1998-2006 (Us$ Billions)
    Figure 1-1: The Size Of Cancer Therapeutic Markets In The Seven Major World Healthcare Markets: 1998-2006
    Figure 1-2: Distribution By Segment Of Cancer Therapeutics Markets: 2000
    Chapter Three: Cancer Epidemiology
    Table 3-1: Populations Of The Major World Healthcare Markets: 1998 - 2006 (Millions)
    Figure 3-1: Trends In The Populations Of The Major World Healthcare Markets: 1998 - 2006 (Millions)
    Table 3-2: Estimated Cancer Prevalence In The Major World Healthcare Markets: 1998 - 2000 (Millions)
    Figure 3-2: Trends In The Cancer Prevalence Rates For The World's Major Healthcare Markets: 1998 - 2006 (Patients Per 100,000 Population)
    Table 3-3: Estimated Incidence (New Cases) Of Selected Cancers In The World's Major Healthcare Markets: 2000 (Thousands)
    Figure 3-3: Distribution Of Major Cancer Incidences In The Seven Major World Healthcare Markets:2000
    Chapter Four: Cancer Therapy Markets
    Figure 4-1: Growth In The Cancer Therapeutics Markets For The Seven Major World Healthcare Markets: 1998 - 2006 (Us$ Billions)
    Table 4-1: Historic And Forecast Market Size For Cancer Therapeutics In The Seven Major World Healthcare Markets: 1998 - 2006 (Us$ Billions)
    Figure 4-2: Historic And Future Growth In Antineoplastic Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006
    Figure 4-3: Historic And Future Growth In Adjunctive And Side-Effect Management Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006 (Billions)
    Table 4-2: Historic And Forecast Market Size For Cancer Therapeutics In The Seven Major World Healthcare Markets By Region: 1998 - 2006 (Us$ Billions)
    Figure 4-4: Historic And Future Growth In Regional Cancer Therapeutic Drug Sales In The Seven Major World Healthcare Markets: 1998 - 2006 (Billions)
    Chapter Five: Current Therapeutic Approaches And Technology
    Table 5-1: Therapeutic Options In The Treatment Of Cancer
    Table 5-2: Commonly Used Chemotherapeutics For Specific Cancers
    Table 5-3: Commonly Used Hormone Therapeutics For Specific Cancers
    Chapter Six: Advanced Cancer Therapeutics And The New Paradigm
    Figure 6-1: Cancer Patient Survival As A Function Of Therapeutic Mode
    Table 6-1: Emerging Cancer Therapies
    Table 6-2: Comparison Of Emerging Cancer Therapies
    Table 6-3: Emerging Cancer Therapies: Developmental Risks
    Figure 6-2: Timeline For Advanced Cancer Therapeutic Development
    Table 6-4: Estimated Peak Market Potentials For Advanced Cancer Therapeutics (Us$ Millions)
    Chapter Seven: Immunological And Vaccine Approaches
    Table 7-1: Cytokines And Growth Factors That Influence The Immune System In Cancer Patients
    Table 7-2: Immune Response-Enhancing Herbs
    Table 7-3: Active Clinical Trials Involving Cancer Immunotherapy
    Chapter Eight: Antiproliferative Approaches
    Table 8-1: Endogenous Angiogenesis Regulators
    Table 8-2: Key Angiongenesis Inhibitors In Development
    Table 8-3: Active Clinical Trials Involving Antiangiogenesis In Cancer Therapy
    Chapter Nine: Photodynamic Therapy
    Table 9-1: Photosensitizers In Application With Cancer Photodynamic Therapy
    Table 9-2: Active Clinical Trials Involving Photodynamic Therapy For Cancer
    Chapter Ten: Gene Therapy Approaches
    Table 10-1: Physical Gene Transfer Technologies
    Table 10-2: Chemically Assisted Gene Transfer Technologies
    Table 10-3: Viral Vector Gene Transfer Technologies
    Table 10-4: Active Clinical Trials Involving Genetic Therapy For Cancer
    Chapter Eleven: Cell Cycle And Apoptosis Approaches
    Table 11-1: Representative Chemotherapeutic Agents Employed On The Basis Of Cell Cycle Selectivity
    Table 11-2: Cell Cycle Regulators
    Table 11-3: Cell Cycle Regulators By Phase

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