• by esalazar@marketresearch.com
  • July 18 2014
  • wound care


No Simple Patch-Ups in the Advanced Wound Care Market

No Simple Patch-Ups in the Advanced Wound Care Market

Gauzes, disinfectants, bandages - even sutures and staples - form the recognizable veneer of wound care and, in terms of their market, obscure the products and innovation most responsible for driving overall market growth. Closer to the patient and working intimately with patients’ own healing response, biological dressings represent promising treatment for a litany of chronic and severe wounds. Kalorama Information expertly explores the terrain and future of the biological dressings market and similarly suited product markets in Advanced Wound Care Markets.

Biological dressings both mimic and replicate original cell structures to be restored at the wound site and proteins and hormones that assist in the healing process. Primary product categories in biological dressings for wound care include skin substitutes (cellular and tissue-based products), collagen dressings, and growth factors. Biological dressings are projected to be the second-fastest growing wound care market segment through 2018 behind only negative pressure wound therapy (NPWT). Biological dressings see the greatest application in the care and treatment of skin ulcers, but are also common in burn treatment and find use in surgical and trauma wound treatment.

Skin substitutes include dermal replacements (engineered to support fibroblasts in the production of a new dermal matrix), epidermal replacements (engineered with keratinocytes in a polymeric film or bioresorbable matrix), and skin replacements including both dermal and epidermal replacement components. Skin substitutes can include allogenic cells (human tissue or graft or cultured cells from another individual), autogenic cells (tissue sourced from elsewhere on the body or cells cultured from the same individual), and xenogenic cells sourced from tissue of another species. Amniotic membrane is prominently used as a skin substitute or ‘scaffolding’ for skin regeneration. The placenta-derived membrane naturally contains several forms of collagen and specialized proteins in an extracellular matrix as well as healing growth factors including the important epidermal growth factor (EGF).  Amniotic membrane also prevents passage of bacteria and other microbes. Companies such as MiMedx, Alliqua Biomedical and Dermasciences produce placental-derived and minimally processed amniotic membranes for grafting over burns and skin ulcers among other wounds.

Collagen is made of extended protein chains and arranged to form fibrils in extracellular space. Collagen in wound dressings most often come from cowhide and is available in sheet, powder and gel forms. The inherently absorbent biomaterial is very useful in wound exudate management. In vivo collagen also plays a significant role in wound healing by guiding the growth of new connective tissue and blood vesels. Exogenous collagen dressing may also help promote granulation tissue formation and the recruitment of macrophages and fibroblasts for wound healing.

Growth factors are a large and diverse group of peptides that coordinate all aspects of interaction between cells. They are signal proteins released from local tissues or blood products that activate target cells to replicate or migrate. Various growth factors contribute to wound healing including epidermal growth factor (EGF), transforming growth factor beta (TGF-beta; stimulates osteoblast deposition of the collagen matrix for wound healing), fibroblast growth factor (aFGF and bFGF), insulin growth factor (IGF-I and II), and platelet-derived growth factor (PDGF; initiates connective tissue healing). Only platelet-derived growth factor has been FDA-approved for wound care as the naturally first growth factor responsible for initiating cell recruitment. Concentrated PDGF has the potential to significantly accelerate the natural wound healing process.

Kalorama Information provides an authoritative guide to global advanced wound care markets with its recent report, which comprehensively profiles market-available products and competitors. The report also features thorough market segmentation in terms of size and distribution across wound type applications and geography.