Ionizing Tea Leaves - Kalorama Explores the Future of Clinical Mass Spectometry

Ionizing Tea Leaves - Kalorama Explores the Future of Clinical Mass Spectometry

The sophistication and analytical flexibility of mass spectrometry systems traditionally excluded them from routine clinical diagnostics. Today, mass spectrometry and its derivative technologies - gas chromatography mass spectrometry (GC-MS), liquid chromatography mass spectrometry (LC-MS), liquid chromatography tandem mass spectrometry (LC-MS/MS), and others - are seeing increasingly wider usage in healthcare. Led by the rising application of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and tandem mass spectrometry, the global clinical mass spectrometry market is projected to grow by roughly 9-10% annually in the coming years.

Demonstrating clinicians’ rising comfort and familiarity with the capabilities of mass spectrometry, surgeons at a Purdue hospital are testing desorption electrospray ionization (DESI) mass spectrometry within a operating room (OR) to assist brain tumor surgery. The technology sprays a charged solvent on the edge surfaces of removed tissue to detect tumor-specific analytes and confirm in real time that brain tumors, otherwise indistinguishable from healthy brain tissue without lengthy pathology examinations, were satisfactorily removed in surgery.

Surgery is just one emerging clinical application of mass spectrometry - the technology is already used in a host of commercialized, regulated applications:

  • MALDI-TOF can be used in small molecule clinical applications to identify pathogens in samples based on cell surface proteins
  • MALDI-TOF can also be used to characterize the antibiotic resistance of pathogens
  • LC-MS/MS is used in toxicology, endocrinology, vitamin D testing, and therapeutic drug monitoring (TDM)
  • Mass spectrometry can be used to detect newly discovered biomarkers unsupported by traditional in vitro diagnostic (IVD) test forms such as immunoassays and clinical chemistry
  • Mass spectrometry has an established role in new born screening for genetic metabolic disorders
  • Diverse clinical applications for mass spectrometry are in development through with laboratory developed tests (LDTs) targeting various diseases, including endocrine disorders and cancer

Kalorama Information’s Mass Spectrometry in Clinical Appications provides a detailed examination of this application market including market revenue segmentation by mass spectrometry system type and manufacturer. The report also includes a laboratory end user survey as well as a thorough review of recent technological trends and current clinical mass spectrometry research.