Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other) - Reagents & Tools, Services, Cell Lines, Models

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Published Oct 7, 2016 | 167 Pages | Pub ID: KLI15126923

Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other)

Genome editing is the process of modifying the DNA of a particular organism, by introducing breaks at specific, targeted locations in the genome. At the present time, ZFNs, TALENs and CRISPR-Cas9 are the most used and commercially developed technologies. The global market for gene editing technologies has exhibited a recent trend of solid growth. Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other) is a market research study that examines the total market, providing revenues and forecasts, including:
  • Global Revenues and Forecast for the Gene Editing Technologies Market by Type of Product, 2014-2020 (Reagents & Tools, Research Services, Genetically-edited Cell Lines, Genetically-edited Animal Models, Total Market)
  • Global Revenues and Forecast for the Gene Editing Technologies Market by Geographic Region, 2014-2020 (North America, Europe, Asia Pacific, ROW)
  • Global Revenues and Forecast for the Gene Editing Technologies Market by Application Area, 2014-2020 (Drug Discovery & Development, Life Sciences Research, Plants/Livestock Engineering, Other Areas, Total Market)
  • Estimated Market Breakdown by Type of Product, 2015 (%) (Reagents & tools, Gene editing services, Edited cell lines, Edited animal models)
  • Estimated Market Breakdown by Geographic Region, 2015 (%) (North America, Europe, Asia Pacific, ROW)
  • Estimated Market Breakdown by Application Area, 2015 (%) (Drug discovery & development, Life sciences research, Plants/livestock engineering, Others)
The report provides revenues and forecasts by technology, including: global revenues and forecast for the CRISPR-based market by type of product, 2014-2020 (reagents & tools, research services, edited cell lines, edited animal models, total market); global revenues and forecast for the ZFN market by type of product, 2014-2020 (reagents & tools, Research services, Edited cell lines, Edited animal models, Total Market); global revenues and forecast for the TALEN market by type of product, 2014-2020 (reagents & tools, research services, edited cell lines, edited animal models, total market); and global revenues and forecast for other gene editing technologies market by type of product, 2014-2020 (reagents & tools, research services, edited cell lines, edited animal models, total market).

The competition has increased in recent years among the companies active in this market, particularly in the CRISPR/Cas9 segment, as new products have been developed and introduced to market. In 2016, multiple players participate in this market, from large multinational corporations to small, niche life sciences companies. These companies develop and commercialize various products and services for each of the major gene editing technologies. Companies profiled in the report include include MilliporeSigma, Horizon Discovery Group, OriGene, ThermoFisher Scientific, and ToolGen.

Gene editing technologies have a multitude of commercial applications in numerous fields, such as the development of human therapeutics, new varieties of plants, new breeds of animals, improved animal models for research, and novel sources of chemicals and energy. Gene Editing Markets (CRISPR-based, Zinc Finger Nuclease [ZFN], TALEN, Other) provides detailed descriptions of these applications.

What Companies Participate in the Gene Editing Market?

In 2016, more than 20 players participate in this market,from large multinational corporations to small, niche life sciences companies.Key players include Millipore Sigma, Dharmcon, GeneCopoeia, Genscript, Horizon Discovery Group, OriGene, ThermoFisher Scientific, Transposagen, and ToolGen.  These companies develop and commercialize various products and services for each of the major gene editing technologies.

Companies profiled in this report include:

Agilent Technologies, Inc.

Allele Biotechnology

Applied Biological Materials, Inc.

Applied StemCell Inc.

Caribou Biosciences, Inc.

Cellectis, Inc.

CRISPR Therapeutics AG

Dharmacon

DNA2.0, Inc.

Editas Medicine

GeneCopoeia

GenScript

Horizon Discovery Group, Plc

Integrated DNA Technologies

Intellia Therapeutics

MilliporeSigma

ZFN Products

CRISPR/Cas9 Genome Editing Tools

OriGene Technologies, Inc.

PNA Bio, Inc.

Precision BioSciences

Sangamo Biosciences, Inc.

Santa Cruz Biotechnology, Inc.

System BioSciences

Takara Bio USA (Clontech Laboratories)

ThermoFisher Scientific

TALEN Products

CRISPR Products

GeneArt Engineered Cell Models

ToolGen, Inc.

Transposagen, Inc.

CRISPR-Cas9 Products

XTN TALEN Products

TriLink Biotechnology

Where Are These Tools Being Sold?

Geographically, in 2016 the market participants are concentrated in the USA. The competition increased in recent years among the companies activating in this market, particularly in the CRISPR/Cas9 segment,as new products were developed and introduced to market. Genome editing is the process of modifying the DNA of a particular organism, by introducing breaks at specific, targeted locations in the genome. In turn, the DNA breaks stimulate the cell’s endogenous repair mechanisms, which are typically non homologous end joining (NHEJ) or homology-directed repair (HDR), depending on the cell state or the presence of a repair template.

What is Genome Editing and NHEJ?

     Genome editing is the process of modifying the DNA of a particular organism, by introducing breaks at specific, targeted locations in the genome. In turn, the DNA breaks stimulate the cell’s endogenous repair mechanisms, which are typically non homologous end joining(NHEJ) or homology-directed repair (HDR), depending on the cell state or the presence of a repair template.

What are the Major Genome Editing Technologies?

The currently available genome editing technologies encompass several classes of programmable nucleases, including mononucleases,zinc finger nucleases (ZFN), transcription activator-like effector nucleases(TALENs), and CRISPR(clustered regularly interspaced short palindromicrepeats)-Cas9 nuclease systems. ZFNs, TALENs and CRISPR-Cas9 are the most used and commercially developed technologies at the present time.

While NHEJ is active throughout the cell cycle, HDR occurs only in dividing cells.  NHEJ repairs the DNA by directly rejoining the two cut ends; however, as NHEJ is an error-prone process, it can introduce insertion or deletion (indel) mutations in the genome that can lead to the degradation of mRNA or the production of truncated proteins,ultimately inactivating the function of that particular gene. On the other hand, in HDR, the lesion is repaired by inserting an exogenous DNA template atthe DNA break location, thus replacing a mutated gene or introducing new genes of interest.  The currently available genome editing technologies encompass several classes of programmable nucleases, including mononucleases, zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALENs), and CRISPR(clustered regularly interspaced short palindromic repeats)-Cas9 nuclease systems. ZFNs, TALENs andCRISPR-Cas9 are the most used and commercially developed technologies at the present time.

ZFNs and TALENs are naturally occurring chimeric enzymes comprising a DNA binding domain fused to a non-specific FokI nuclease domain with DNA-cleaving activity. They recognize DNA sequences through DNA-protein interactions, and contain modules that target a small number of nucleotides –one in the case of TALENs, and three in that of ZFNs.  In the case of ZFNs, the DNA binding domainis a dimeric array of zinc finger proteins, which are synthetically-prepared zinc finger proteins consisting of 30 amino acid Gene Editing Markets

While NHEJ is active throughout the cell cycle, HDR occurs only in dividing cells.  NHEJ repairs theDNA by directly rejoining the two cut ends; however, as NHEJ is an error-prone process, it can introduce insertion or deletion (indel) mutations in the genome that can lead to the degradation of mRNA or the production of truncated proteins,ultimately inactivating the function of that particular gene. On the other hand, in HDR, the lesion is repaired by inserting an exogenous DNA template at the DNA break location, thus replacing a mutated gene or introducing new genes of interest.  Current Major Genome Editing Technologies

What Applications Are These Technologies Used For?

A lot of the use of gene editing is still being sorted out by researchers and regulators, but drug development is a key area.  Also plant and livestock engineering, basic life science research and a host of other areas.   

 

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