Human Microbiome Applications in IVD and Other Healthcare

 
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Published Dec 6, 2017 | 280 Pages | Pub ID: KLI15545428

Human Microbiome Applications in IVD and Other Healthcare

The human body contains trillions of microbes. The term “microbiome” is used to refer to this community of microorganisms. Researchers increasingly consider the microbiome’s complicated relationship with its human host crucial to health.

Human Microbiome Applications in IVD and Other Healthcare
surveys the growing interest in the human microbiome in in vitro diagnostics (IVD) and other healthcare applications, touching on areas such as metagenomics, metabolomic profiling, and microbiome diagnostics, among others.

While study of the microbiome has attracted enthusiastic media attention and venture capital, its findings are largely preliminary. Still, some IVD companies have already launched tests to measure changes in the microbiome to monitor disease progress. Human Microbiome Applications in IVD and Other Healthcare notes selected molecular microbiome-based tests, microbiome-based diagnostic biomarkers, and precision or personalized medicine approaches to the microbiome.

Human Microbiome Applications in IVD and Other Healthcare notes pharmaceutical company interest in the microbiome as well. Spurred on by the Human Microbiome Project, pharmaceutical companies have become more interested in microbiome research. Many players in the microbiome market are amassing knowledge and data about the microbiome in order to partner with pharmaceutical firms interested in developing new therapeutics. Microbiome-based therapeutic approaches are discussed, including fecal microbiota transplants (FMT) and selected novel therapies. Select current microbiome-related drug candidates are noted in Human Microbiome Applications in IVD and Other Healthcare as well.

Microbiome companies and start-ups offer a wide array of products and services. They can be roughly grouped into therapeutics-based companies, research-based companies, and direct-to-consumer service providers. Despite the fact that efforts to develop microbiome-based diagnostics and therapies remain in their early stages, microbiome companies have attracted significant investment, which is discussed in the report.

Company Profiles

Human Microbiome Applications in IVD and Other Healthcare profiles players in the microbiome market, companies involved in testing, therapeutics, sample preparation and processing, and more, including:
  • 4D Pharma plc
  • Abbott Diagnostics
  • Abbvie
  • Aces Health
  • AdvancingBio
  • Agilent Technologies Inc.
  • Anaeropharma Science
  • AOBiome, LLC
  • Aperiomics, Inc.
  • Arivale
  • Atlas Biomed
  • AvidBiotics
  • Beckman Coulter / Danaher
  • Becton, Dickinson and Company (BD)
  • Biocartis Group
  • The BioCollective
  • BioGaia Pharma AB
  • Biohit OYJ
  • Biomecite Diagnostics
  • bioMérieux Inc.
  • Bio-Rad Laboratories, Inc.
  • Biose
  • Blis Technologies
  • Bruker Corporation
  • C3J Therapeutics (formerly C3 Jian)
  • Capsugel
  • Charles River Laboratories, Inc.
  • CIPAC Therapeutics
  • CLC bio (a QIAGEN company)
  • Clinical-Microbiomics
  • Copan Diagnostics, Inc.
  • CosmosID
  • Covaris
  • Crestovo (Finch Therapeutics Group)
  • Danaher Corporation
  • Dermala
  • DermTech
  • Diversigen
  • DNA Genotek
  • DNAnexus, Inc.
  • Eagle Genomics
  • Eligo Bioscience
  • ENTEROME Bioscience SA
  • EpiBiome
  • Eppendorf AG
  • Evelo Biosciences
  • Evolve Biosystems
  • Finch Therapeutics Group
  • GALT
  • GATC Biotech AG
  • Genetic Analysis AS
  • GENEWIZ, Inc.
  • GlaxoSmithKline plc
  • Human Longevity, Inc. (HLI)
  • Illumina
  • IS-Diagnostics
  • ISOThrive LLC
  • Janssen Biotech (Johnson & Johnson)
  • Kallyope
  • Labcyte
  • Luminex Corporation
  • Mayo Medical Laboratories
  • Menarini-Silicon Biosystems
  • Merck & Co., Inc.
  • Metabiomics Corporation
  • MetaboGen AB
  • Metabolon, Inc.
  • Microbiome
  • Microbiome Insights
  • MicroBiome Therapeutics (MBT)
  • Mitra Biotech
  • MyBiotics
  • Naked Biome
  • Nestlé Health Science
  • New England Biolabs
  • Nizo
  • Norgen Biotek
  • OncoImmunity
  • One Codex
  • OpenBiome
  • Optibiotix
  • OraSure Technologies, Inc.
  • Osel, Inc.
  • PerkinElmer, Inc. (Pe)
  • Pfizer, Inc.
  • Phase Genomics
  • Proderm IQ
  • Prodigest
  • Promega Corporation
  • PureFlora Inc.
  • QIAGEN
  • Quay Pharma
  • Rebiotix
  • Resphera Biosciences
  • Ritter Pharmaceuticals, Inc.
  • Roche Diagnostics
  • Sabinsa Corporation
  • ScreenCell
  • Second Genome
  • Seres Therapeutics
  • Shimadzu Corporation
  • Siolta Therapeutics
  • Symbiotic Health
  • SynCo Bio Partners B.V.
  • Synlogic
  • Synthetic Biologics
  • Thermo Fisher Scientific, Inc.
  • TNO
  • Triskelion
  • uBiome
  • Vaiomer
  • Vedanta Biosciences
  • VIOME
  • ViThera Pharmaceuticals
  • Waters Corporation
  • Whole Biome
  • Xycrobe Therapeutics, Inc.
  • Zymo Research
The information presented in this report is the result of data gathered from government reports, company product literature and other corporate brochures and documents, as well as information found in the scientific and trade press.

Visit Kalorama Information's 'In Vitro Diagnostics' curated page for complete coverage of the IVD market.

1: EXECUTIVE SUMMARY
INTRODUCTION
LARGE-SCALE MICROBIOME PROJECTS
SCOPE OF THE REPORT
METHODOLOGY
2: HUMAN MICROBIOME IN IVD AND OTHER HEALTHCARE APPLICATIONS
MICROBIOME – BACTERIA IN DISEASE PROCESSES
GROWING INTEREST IN THE MICROBIOME
METAGENOMICS
METABOLOMIC PROFILING
MICROBIOME DIAGNOSTICS
Table 2-1: Selected Microbiome-based Tests
Selected Molecular Microbiome-based Tests
Diagnostic Biomarkers
Precision or Personalized Medicine Approaches
PHARMA COMPANY INTEREST IN THE MICROBIOME
Agreements, Investments
Fecal Microbiota Transplantation (FMT)
Other Selected Microbiome-related Therapeutic Approaches
Microbiome Modulators
INVESTMENT IN MICROBIOME COMPANIES
Table 2-2: Selected Investments in Microbiome Companies
3: SELECTED MICROBIOME PLAYERS
4D PHARMA PLC
GT Biologics
ABBOTT DIAGNOSTICS
Company Overview
IRIDICA
The Microbiome Coalition
ABBVIE
Synlogic Partnership
ACES HEALTH
ADVANCINGBIO
AGILENT TECHNOLOGIES INC.
ANAEROPHARMA SCIENCE
AOBIOME, LLC
APERIOMICS, INC.
ARIVALE
ATLAS BIOMED
AVIDBIOTICS
Pylum Biosciences, Inc.: Microbiome-focused Company with Precision Anti-Bacterial Technology
Xyphos, Inc.: Immuno-Oncology Focused Company with Flexible CAR-T Technology
BECKMAN COULTER / DANAHER
BECTON, DICKINSON AND COMPANY (BD)
Cytology
BD Max Molecular
ID/AST
POC Veritor
Mass Spectrometry
Blood Collection
Flow Cytometry
Licensing
BIOCARTIS GROUP
Microbiome
Company Overview
THE BIOCOLLECTIVE
BIOGAIA PHARMA AB
BIOHIT OYJ
Microbiome
Company Overview
Market Expansion
BIOMECITE DIAGNOSTICS
BIOMÉRIEUX INC.
Traditional Microbiology
Blood Culture
Immunoassays
Mass Spectrometry
Platelet Safety
Sequencing
Sequencing – Sample Preparation, Molecular
Data Analysis
BioFire Diagnostics Business
BIO-RAD LABORATORIES, INC
Microbiome
Company Overview
Quality Control
Blood Bank
Infectious Diseases - Molecular
Immunoassays
Liquid Biopsy
Droplet Digital PCR
Sequencing
BIOSE
BLIS TECHNOLOGIES
BRUKER CORPORATION
Microbiome
Company Overview
C3J THERAPEUTICS (FORMERLY C3 JIAN)
CAPSUGEL
CHARLES RIVER LABORATORIES, INC.
Microbiome
History and Lines of Business
Drug Discovery Services
CIPAC THERAPEUTICS
CLC BIO (A QIAGEN COMPANY)
CLINICAL-MICROBIOMICS
COPAN DIAGNOSTICS, INC.
Lab Automation
Partnerships
Swabs
COSMOSID
COVARIS
Sample Prep for Microbiome Research
Company Overview
CRESTOVO (FINCH THERAPEUTICS GROUP)
DANAHER CORPORATION
Company Overview
Mass Spectrometry
Danaher Buys Phenomenex
DERMALA
DERMTECH
DIVERSIGEN
DNA GENOTEK
DNANEXUS, INC
EAGLE GENOMICS
ELIGO BIOSCIENCE
ENTEROME BIOSCIENCE SA
Bristol-Myers Squibb
Vertex Pharmaceuticals
Takeda Pharmaceutical
Janssen Biotech
Nestle Health Science
EPIBIOME
Company Overview
Partnerships and Collaborations
EPPENDORF AG
EVELO BIOSCIENCES
EVOLVE BIOSYSTEMS
FINCH THERAPEUTICS GROUP
GALT
GATC BIOTECH AG
GENETIC ANALYSIS AS
Company Overview
Agreement with Bio-Rad
GENEWIZ, INC.
GLAXOSMITHKLINE PLC
Company Overview
Microbiome-related Developments
HUMAN LONGEVITY, INC. (HLI)
ILLUMINA
Sequencing
Microbiome-related Developments
IS-DIAGNOSTICS
ISOTHRIVE LLC
JANSSEN BIOTECH (JOHNSON & JOHNSON)
The Janssen Human Microbiome Institute (JHMI)
Table 3-1: Janssen Human Microbiome Institute (JHMI), Already Existing Microbiome Collaborations with Biotechnology Companies and Academic Institutions, February 2015
MOSAIC Microbiome Platform
License Agreement with Vedanta Biosciences
KALLYOPE
LABCYTE
LUMINEX CORPORATION
Microbiome-related Developments
Company Overview
Assay Development
Verigene Business
Business Expansion
MAYO MEDICAL LABORATORIES
MENARINI-SILICON BIOSYSTEMS
MERCK & CO., INC.
METABIOMICS CORPORATION
METABOGEN AB
METABOLON, INC.
Company Overview
Precision Metabolomics
Partnerships and Collaborations
MICROBIOME
MICROBIOME INSIGHTS
MICROBIOME THERAPEUTICS (MBT)
Company Overview
Technology
MITRA BIOTECH
MYBIOTICS
NAKED BIOME
NESTLÉ HEALTH SCIENCE
Company Overview
Microbiome-related Development
NEW ENGLAND BIOLABS
Company Overview
Microbiome-related Development
NIZO
NORGEN BIOTEK
ONCOIMMUNITY
ONE CODEX
Company Overview
Microbiome-related Development
OPENBIOME
Company Overview
Finch Therapeutics
OPTIBIOTIX
Company Overview
Technology Platforms
ORASURE TECHNOLOGIES, INC.
Company Overview
The Genotek Business
OSEL, INC.
Company Overview
Portfolio
PERKINELMER, INC. (PE)
Company Overview
Diagnostics
Sample Prep
Sequencing
Histology
Prenatal Business
Lab Services
Expansion
PFIZER, INC.
PHASE GENOMICS
PRODERM IQ
PRODIGEST
PROMEGA CORPORATION
PUREFLORA INC.
QIAGEN
QIAGEN Bioinformatics
QUAY PHARMA
REBIOTIX
RESPHERA BIOSCIENCES
RITTER PHARMACEUTICALS, INC.
Company Overview
RP-G28
ROCHE DIAGNOSTICS
Company Overview
Microbiome-related Developments
SABINSA CORPORATION
SCREENCELL
SECOND GENOME
SERES THERAPEUTICS
Collaboration with The University of Texas MD Anderson Cancer Center and the Parker Institute for Cancer Immunotherapy
Biotherapies for Infection Treatment
Selected Products in Development
SHIMADZU CORPORATION
SIOLTA THERAPEUTICS
SYMBIOTIC HEALTH
SYNCO BIO PARTNERS B.V.
SYNLOGIC
Company Overview
AbbVie Partnership
SYNTHETIC BIOLOGICS
Company Overview
SYN-004 (ribaxamase)
SYN-010
THERMO FISHER SCIENTIFIC, INC.
Microbiome-related Development
Company Overview
TNO
TRISKELION
UBIOME
VAIOMER
VEDANTA BIOSCIENCES
VIOME
VITHERA PHARMACEUTICALS
WATERS CORPORATION
WHOLE BIOME
XYCROBE THERAPEUTICS, INC.
Company Overview
Research Agreement with Johnson & Johnson Consumer
ZYMO RESEARCH

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