Published May 13, 2015 |
165 Pages |
Pub ID: KLI5556567
Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays. Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways. This report defines the proteomics research market for major technologies.
Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis. As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups:
• Mass Spectrometry
• Liquid Chromatography
Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world. Proteomics is only one strand of systems biology or one of several “omics” fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the “omics,” proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment. This report also explores proteomics research market by the current and forecast size of disease group market segments that include:
As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis.
The report notes the background, products and revenue of the major market players. Companies profiled include:
• AB Sciex (Danaher)
• Agilent Technologies
• Bruker Corporation
• Thermo Fisher Scientific
• Waters Corporation
• Bio-Rad Laboratories
• GE Healthcare Life Sciences
• JEOL Ltd.
• Shimadzu Corporation
No market assessment of proteomics research is complete without a thorough discussion of its instrument-based core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie. The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis. Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively ‘antibody-less’ workflow.
This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications:
• Triple Quadrupole (QqQ)
• Time-of-flight (TOF)
• Quadrupole-TOF (Q-TOF)
• Ion Traps (IT,QIT,LIT)
The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials. Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically.
The following is among the topics addressed in this report:
• Current Practices in Drug Discovery
• The Translational Research Workflow
• Proteomics in Biomarker Research
• Biomarker Discovery
• Biomarker Verification
• Biomarker Validation
• Company Market Shares by Research Instrument
• Company Revenues and Detailed Product Offerings
• Analyst Conclusions Regarding the Present and Future Market
Kalorama Information's market analysis is worldwide and this report breaks out the market for proteomic research into geographic regions. North America is the dominant regional market for proteomics research with instrumentation distributed widely among universities, research centers, medical centers, core pharmaceutical laboratories, and specialty contract research organizations (CROs) focusing on biomarker development. Asia-Pacific is expected to see build-up of proteomics instrumentation capacity following the same trajectory of genomics research development in the region. The report defines the geographic trend in the market and provides specific proteomic research market sizes for the following regions.
• United States
• Rest of World (ROW)