Transplant Matching Molecular Diagnostics Market

Apr 28, 2017
50 Pages - Pub ID: KLI15334860
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Molecular HLA typing methods allow more precise matching between donor and recipient and is especially critical to bone marrow or HSCT transplant outcomes. Allogenic HSCT transplantation is a relatively high growth procedure area compared to solid organ transplantation and is a leading area of application for molecular HLA typing. Polymorphism in the human major histocompability complex (MHC) or HLA system is exceedingly complex for serological methods and is best captured by directly assaying genetic sequence.  This report, Transplant Matching Molecular Diagnostics Market provides: 

  • United States Molecular Transplant Diagnostics Market, 2016 -2021

  • Europe Molecular Transplant Diagnostics Market, 2016 -2021

  • Japan Molecular Transplant Diagnostics Market, 2016 -2021

  • Rest of World Molecular Transplant Diagnostics Market, 2016 -2021

  • Global Molecular Procedure Volumes, 2016 to 2021 

  • Global Molecular Transplant Diagnostics Market Share by Vendor

The molecular HLA typing market is provided for various regions, and forecasts are made to 2021.   In addition the report discusses trends affecting the molecular transplant matching market.  Successful solid organ and hematopoietic stem cell (HSCT) or bone marrow transplants require histocompatibility between the recipient and donor. Autologous transplantation using hematopoietic cells from the same patient (donor and recipient) is increasingly common and eliminates the need to screen for histocompatibility. However, solid organ transplants and HSCT allografts from another donor requires histocompatibility confirmed by human leukocyte antigen (HLA) testing outside of genetically identical twins.

Proteins encoded by HLA system genes function as unique cell surface markers that regulate immune system recognition of foreign cells such as pathogens and tumor cells. Incompatibility between donor and recipient HLA systems or between donor tissue and recipient antibodies can result in severe complications such as transplant rejection. Testing of donor and recipient HLA systems is essential in cases of allograft between unrelated and even siblings. The most common forms of HLA typing are serological testing of HLA antigens and antibodies and detection of HLA alleles using a variety of molecular diagnostic techniques. Next-generation sequencing (NGS) is expected to develop into a leading option for the determination of HLA alleles.

As part of its coverage of this market, the report also discusses molecular diagnostics technologies and the state of the molecular diagnostics business.  The following companies are profiled as part of this report:

  • CareDX
  • Illumina
  • Immucor
  • Roche Diagnostics
  • Thermo Fisher Scientific
1: EXECUTIVE SUMMARY
  • Introduction
  • Transplant Diagnostics Market Analysis
  • Molecular Diagnostics in Healthcare
  • Global Molecular Diagnostics Market
2: TRANSPLANT MATCHING AND MOLECULAR TECHNOLOGY
  • Transplant Matching
  • Procedure Volume
  • Table 2-1: Transplant Matching Procedure Volume, 2016 - 2021
  • Clinical Molecular Technologies
  • Nucleic Acid Amplification Test (NAATt) Technologies
  • Real-Time PCR (qPCR)
  • Sequencing
3: MOLECULAR TRANSPLANT DIAGNOSTICS MARKET AND MARKET SHARE ANALYSIS
  • Introduction
  • Market Analysis
  • Regional Market Analysis
  • Figure 3-1 Global Molecular Transplant Diagnostics Market (2016) – United States, Europe, Japan, Rest of World ($ Millions)
  • Figure 3-2 Global Molecular Transplant Diagnostics Market (2016-2021) – United States, Europe, Japan, Rest of World ($ Millions)
  • Market Share Analysis
  • Figure 3-3 Global Molecular Transplant Diagnostics Market Share - Thermo Fisher Scientific, Immucor, Caredx, Others (%)
  • Technological Shift to Next-Generation Sequencing And Real-Time PCR
  • Conclusions
4: COMPANY PROFILES
  • CareDx
    • Sequencing
    • Molecular HLA Typing
  • Illumina
    • Sequencing
    • Translational Research
    • Clinical Assay Development
    • Industry Lab-Developed Tests
    • Arrays
  • Immucor
    • Transfusion Diagnostics
    • Transplant Diagnostics
    • Immucor Dx Laboratory Service
  • Roche Diagnostics
    • Molecular Diagnostics
  • Thermo Fisher Scientific
    • Transplant Diagnostics
    • qPCR
    • Sequencing

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