This report analyzes the current and potential world market for components used in downstream processing, or bioprocessing. This report generally reviews the nature and direction of research, as well as future markets. In the downstream bioprocessing market, companies profiled include ESI Ultrapure, GE Healthcare, Millipore, Natrix, Pall, Sartorius, and Thermo Fisher Scientific, among others.

Downstream processing, or bioprocessing, involves the separation or purification of biological products. Downstream processing implies manufacture of a purified product for a specific use, in marketable quantities, and as far as this report is concerned, for use in clinical medicine.

Even though bioprocessing steps are complicated and complex, outsourcing has become very popular. In many instances now, bioprocessors are outsourcing a variety of functions, such as process development, research, testing, validation, and bioprocessing design, among others. Manufacturers harness outsourcing to eliminate the need to construct expensive specialized facilities or hiring and training staff.

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Table Of Contents

  • Executive Summary
    • Overview
      • Focus on Cost Effectiveness
      • Outsourcing Popular
      • Flexibility and More Research Needed
        • Table World Market for Downstream Bioprocessing Components, 2016-2021 ($ billions)
    • Methodology
  • Introduction
    • Downstream Processing
      • Table The State of Downstream Bioprocessing
      • Important Roles
        • Table Key Roles of Downstream Bioprocessing
      • Safety and Efficacy
    • Stages of Downstream Processing
      • Table Stages of Downstream Bioprocessing
      • Solid-Liquid Separation
      • Intracellular Product Release
      • Product Concentration
      • Chromatography Purification
      • Formulation
    • Changes in Production Nature
      • Table Current Biopharmaceutical Product Mix
      • Innovation Required
      • Globalization Continues
    • The Need for Operational Excellence
    • Competition Generating Cost Efficiencies
      • Downstream Resistance
      • Process Intensification
      • Higher Titers
      • New Technologies
      • Flexibility
      • Integration and Automation
      • Continuous Processing
    • Developing Research Areas
      • Chromatography
      • Resins
      • Alternative Processes for Purification
      • Spectroscopy
    • Filtration Technologies Advance
      • Tangential Flow
      • Automated
      • Gel Filtration Chromatography
      • Precipitation Alternative
      • Slow Adoption of New Technologies
    • Outsourcing
      • Core Competencies
      • Drivers
      • Issues
      • The Future
  • Trends and Drivers
    • Table Key Trends in Downstream Bioprocessing
    • Protein A
    • Molecule Issues
    • Chromatography
      • Table Application of Single Use Technology Downstream (percentage of overall use)
    • Streamlining and Redesigning
      • Streamlining Niches
    • Purification
    • Greater Use of Contract Manufacturers
    • Production Efficiency
    • International
    • Cancer Therapy Push
    • Collaborations and Innovation
  • Challenges
    • Chromatography
    • Continuous Processing
    • Titers and Composition
    • Evolving Clarification and Purification Strategies
    • Capacity Bottlenecks
    • Isolation of Proteins
    • Efficiencies
    • Quality by Design
    • Talent Shortage
  • Market Developments
    • Collaboration to Improve Downstream Bioprocessing
    • Start-up Acquisition
    • Promoting Pre-Packed Columns
    • Next Generation Columns
    • Next Generation Affinity Ligands
    • Immunoglobulin Facility
    • Bioprocessing Services
    • Expansion
    • Acquisition
    • Supply Deal
    • Bioconjugation Process
    • New Structured Substrates
    • New Protein A Chromatography Resin
    • Enterprise Software Increases Throughput and Quality
    • Investing in Protein Expression Platform
  • Market Landscape
    • Overview
    • Drivers
      • Table Key Drivers of Downstream Bioprocessing
      • Expanding Therapies and Markets
    • Market Analysis and Forecasts
      • Biosimilars
      • Growth and Emerging Markets
      • Continuous Processing
    • Global Market for Downstream Bioprocessing Components
      • Table Downstream Components Bioprocessing Market Share by Vendor 2018 (%)
      • Table World Downstream Bioprocessing Markets, 2016-2021 ($ billions)
      • Table World Downstream Bioprocessing Markets by Geography, 2016-2021 ($ billions)
      • Table World Downstream Bioprocessing Markets by Geography, 2017 (%)
      • Chromatography Columns and Resins
        • Table World Downstream Bioprocessing Chromatography Columns and Resins Markets, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2017 (%)
      • Membrane Adsorbers
        • Table World Downstream Bioprocessing Membrane Adsorber Market, 2016-2021 ($ millions)
        • Table World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2016-2021 ($ millions)
        • Table World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2017 (%)
      • Filtration Systems
        • Table World Downstream Bioprocessing Filtration Market, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Filtration Market by Geography, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Filtration Market by Geography, 2017 (%)
      • Sensors
        • Table World Downstream Bioprocessing Sensor Market, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Sensor Market by Geography, 2016-2021 ($ billions)
        • Table World Downstream Bioprocessing Sensor Market by Geography, 2017 (%)
  • Corporate Profiles
    • 3M Company, St. Paul, MN 55144, www.3m.com/3M/en_US/company-us
    • Abec, Bethlehem, PA 18017, www.abec.com
    • Alfa Laval, Lund, Sweden, www.alfalaval.com
    • Avantor Performance Materials, Center Valley, PA 18034, www.avantorinc.com
    • BIA Separations, Ajdovšèina, Slovenia, www.biaseparations.com
    • Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877, www.bioxcellence.com
    • Bosch, Stuttgart, Germany, www.bosch.de/en/
    • Dow, Midland, MI, www.dow.com
    • ESI Ultrapure, Cwmbran, Torfaen, NP44 3XS, UK, www.esiultrapure.com
    • Finesse Solutions, Santa Clara, CA 95054, www.finesse.com
    • FujiFilm Diosynth biotechnologies, College Station, TX 77845, www.fujifilmdiosynth.com
    • GE Healthcare Life Sciences, Marlborough, MA 01752, https://www.gelifesciences.com/ solutions/bioprocessing/productsand- solutions/downstream-bioprocessing
    • GEA Germany Düsseldorf, 40468 Düsseldorf, Germany, www.gea.com/en
    • Lonza Group, Basel, Switzerland, www.lonza.com
    • Millipore, Millipore Sigma, Burlington, MA 01803, www.emdmillipore.com
    • Natrix Separations, Burlington, Ontario, L7L 6A8 Canada, www.natrixseparations.com
    • Nordson Medical, Marlborough, MA 01752, www.nordsonmedical.com
    • Pall Biotech, Port Washington, NY 11050, https://biotech.pall.com
    • Parker Hannifin, Cleveland, OH 44124, www.parker.com
    • Repligen, Waltham, MA 02453, www.repligen.com
    • Sartorius AG, Goettingen, Germany, www.sartorius.com
    • Thermo Fisher Scientific, Waltham, MA 02451, https://www.thermofisher.com/us/en/home/lifescience/ bioproduction.html
    • W. L. Gore & Associates, Inc., Newark, DE 19711, www.gore.com
    • Watson-Marlow Fluid Technology Group, Falmouth, TR11 4SZ UK, www.watson-marlow.com