This report focuses on the market for NGS library preparation and target enrichment products, which includes the hardware and consumables. It discusses trends, challenges, strategies, companies, and products, and provides estimates of market share and revenue growth for the market. The competitive situation, deals, and litigation are covered in respective chapters. The report was produced through a combination of primary research, secondary research, and internal databases, including SEC filings, product literature, corporate websites, conferences, journals, and trade publications.

The DNA sequencer market had been relatively stable before about 2006, with a dominant vendor, Applied Biosystems, and relatively few changes taking place in the products or technologies. The growth in second-generation system sales grew rapidly from 2007 to 2011, but revenue growth is declining as lower cost systems become available and the market becomes somewhat saturated at the high end. Several companies are developing technologies that could again disrupt the market.

This report concludes with strategic recommendations aimed to help readers navigate the industry.

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Table Of Contents

  • Executive Summary
    • Introduction
    • Product Introductions, Indications of Price Pressure
    • Stability in Sequencers Appears to Be Continuing
    • A Period of Rapid Adoption, But Lower Prices
    • High Likelihood of Longer-Term Challenges
    • Size and Growth of the Market
    • Background
    • Scope and Methodology
    • Applications and Definitions
  • Library Prep and Target Enrichment Trends
    • Falling Costs, Improved Output, Smaller and Simpler
    • Broad Range of Deals and Acquisitions
    • Technologies Continuing to Push Boundaries
    • China Becoming Major Player in Market
    • More Systems Stalled or Cancelled
    • Gradual Acceptance and Validation of Clinical Applications
    • Success in Microbiology and Pathogen Detection
    • Regulatory Trends
    • Gradual but Rocky Progress with Regulation and Reimbursement
  • Library Prep and Target Enrichment Products
    • Table Selected Library Prep and Target Enrichment Products / Technologies Offered
  • NGS Library Prep and Target Enrichment Market Revenues
    • Revenues Forecast
      • Table Cost of Sequencing a Genome
      • Table NGS Sample Preparation Revenues, 2017-2022 ($M)
      • Table NGS Sample Preparation Growth Rate, 2017-2022 (%)
      • Table NGS Sample Preparation Revenues, 2017-2022 ($M)
      • Table NGS Sample Preparation Growth Rate, 2017-2022 (%)
    • Revenues by Region
      • Table NGS Sample Preparation Revenues by Region, 2017 (N. America, Europe, Asia-Pacific, Rest-of- World) ($M)
      • Table NGS Sample Preparation Revenues by Region, 2017 (N. America, Europe, Asia-Pacific, Rest-of- World) (%)
    • Illumina Consumables Revenues
      • Table Illumina Quarterly Consumables Revenues (2014-2018) ($M)
      • Table Illumina Quarterly Consumables Revenues (2014-2018) ($M)
      • Table Illumina Consumables Shares (2012-2017) ($M)
      • Table Illumina 2012 Sequencing Consumables Share (%)
      • Table Illumina 2017 Sequencing Consumables Share (%)
      • Table Illumina Consumables Growth Rates, 2013-2017 (%)
  • Competitive Analysis
    • Introduction
      • Continued Growth and Technology Advances
      • Sequencer Battles Turn Somewhat Calm
    • Library Preparation and Target Enrichment Market Shares
      • Table Library Preparation and Target Enrichment Market Shares by Company, 2017 ($M, %)
      • Table Library Preparation and Target Enrichment Market Shares by Company, 2017 (%)
    • Smaller Companies Experiencing Mixed Success
  • Intellectual Property and Litigation
    • Pacific Biosciences and Oxford Nanopore
    • Several NIPT Companies Fighting
    • Ariosa Diagnostics (Roche) Files Suit against Sequenom
    • Natera Sues Sequenom; Sequenom Sues Natera
    • Verinata Health and Stanford File against Sequenom
    • Verinata Health against Ariosa and LabCorp
    • Illumina Sues Ariosa Diagnostics for NIPT Test
    • Illumina Sues Premaitha Health for NIPT Test
    • Sequenom and Illumina Settle and Pool Patents
    • Sequenom Petitions Supreme Court
    • Illumina's Conflicts with Oxford Nanopore
    • Enzo Biochem Brings Suit against Numerous Companies
    • 454 (Roche) Sues Ion Torrent (Thermo Fisher)
    • RainDance Technologies Sues 10X Genomics
    • 10X Genomics' Dispute with Bio-Rad
    • Sequenom Shareholder Sues over Price "Capping"
    • Class Action Shareholder Lawsuit Filed against Pacific Biosciences
    • Helicos' Patent Infringement Suit against PacBio, Life Technologies, and Illumina
    • Illumina's Two Lawsuits against Complete Genomics for Infringement
    • Life Technologies and Illumina Dispute over Amplification on Solid Surfaces
    • Life Technologies Files Infringement Suit against Promega
    • Enzo Biochem Disputes Sequencing Patents
    • Azco Biotech Sues Qiagen and Intelligent Bio-Systems
    • Intelligent Bio-Systems (Qiagen) and Columbia University Sue Illumina for Infringement
    • LabCorp's Esoterix Sues Life Technologies
    • Genetic Technologies Sues Several Firms for Infringement of Haplotype Determination Technique
    • Illumina Sues Life Technologies over Ion Torrent Systems
    • Life Technologies Defeats VisiGen Stakeholders after Arbitration
    • Catalyst Assets Sues Life Technologies for Infringement
    • Patent Interference between Life Technologies and Pacific Biosciences
    • LadaTech Sues Illumina over DNA Amplification Patent
    • Illumina Files `841 Patent Infringement Suit against Affymetrix
    • Affymetrix and Illumina Settle Case over `243, `432, `531, `365, and `716
    • Applied Biosystems and Illumina Claims and Counter-claims over Sequencing-by-Ligation Both Unsuccessful
  • Library Prep and Target Enrichment Market Deals
    • Table Recent Selected Significant Collaborations in the NGS Library Preparation and Target Enrichment Market
  • Corporate Profiles
    • 10X Genomics
    • Agilent Technologies
    • F. Hoffmann-La Roche AG
    • Fluidigm
    • Illumina
    • New England Biolabs
    • Oxford Nanopore
    • Pacific Biosciences
    • Qiagen
    • Thermo Fisher Scientific
  • Challenges and Strategic Recommendations
    • Challenges
    • Strategic Recommendations